Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots
Publication Date
March 09, 2017
Authors
Natalia Gordya, Andrey Yakovlev, Anastasia Kruglikova, Dmitry Tulin, et al
Volume
12
Issue
3
Pages
e0173559
DOI
https://dx.plos.org/10.1371/journal.pone.0173559
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0173559
Scopus
85014840762
Mendeley
http://www.mendeley.com/research/natural-antimicrobial-peptide-complexes-fighting-antibiotic-resistant-biofilms-calliphora-vicina-med
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots", "type"=>"journal", "authors"=>[{"first_name"=>"Natalia", "last_name"=>"Gordya", "scopus_author_id"=>"54402816600"}, {"first_name"=>"Andrey", "last_name"=>"Yakovlev", "scopus_author_id"=>"23399079300"}, {"first_name"=>"Anastasia", "last_name"=>"Kruglikova", "scopus_author_id"=>"54385447000"}, {"first_name"=>"Dmitry", "last_name"=>"Tulin", "scopus_author_id"=>"6506009104"}, {"first_name"=>"Evdokia", "last_name"=>"Potolitsina", "scopus_author_id"=>"57193554103"}, {"first_name"=>"Tatyana", "last_name"=>"Suborova", "scopus_author_id"=>"23499763100"}, {"first_name"=>"Domenico", "last_name"=>"Bordo", "scopus_author_id"=>"7003350324"}, {"first_name"=>"Camillo", "last_name"=>"Rosano", "scopus_author_id"=>"7004092715"}, {"first_name"=>"Sergey", "last_name"=>"Chernysh", "scopus_author_id"=>"6602134087"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1111111111", "pmid"=>"28278280", "scopus"=>"2-s2.0-85014840762", "pui"=>"614718960", "doi"=>"10.1371/journal.pone.0173559", "sgr"=>"85014840762"}, "id"=>"b993451d-3618-3c15-84f8-9c077ad5420c", "abstract"=>"Biofilms, sedimented microbial communities embedded in a biopolymer matrix cause vast majority of human bacterial infections and many severe complications such as chronic inflammatory diseases and cancer. Biofilms' resistance to the host immunity and antibiotics makes this kind of infection particularly intractable. Antimicrobial peptides (AMPs) are a ubiq-uitous facet of innate immunity in animals. However, AMPs activity was studied mainly on planktonic bacteria and little is known about their effects on biofilms. We studied structure and anti-biofilm activity of AMP complex produced by the maggots of blowfly Calliphora vicina living in environments extremely contaminated by biofilm-forming germs. The complex exhibits strong cell killing and matrix destroying activity against human pathogenic antibiotic resistant Escherichia coli, Staphylococcus aureus and Acinetobacter baumannii biofilms as well as non-toxicity to human immune cells. The complex was found to contain AMPs from defensin, cecropin, diptericin and proline-rich peptide families simultaneously expressed in response to bacterial infection and encoded by hundreds mRNA isoforms. All the families combine cell killing and matrix destruction mechanisms, but the ratio of these effects and antibacterial activity spectrum are specific to each family. These molecules dramatically extend the list of known anti-biofilm AMPs. However, pharmacological development of the complex as a whole can provide significant advantages compared with a conventional one-component approach. In particular, a similar level of activity against biofilm and planktonic bacteria (MBEC/MIC ratio) provides the complex advantage over conventional antibiotics. Available methods of the complex in situ and in vitro biosynthesis make this idea practicable.", "link"=>"http://www.mendeley.com/research/natural-antimicrobial-peptide-complexes-fighting-antibiotic-resistant-biofilms-calliphora-vicina-med", "reader_count"=>21, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>5, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>8, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"India"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85014840762"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85014840762?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85014840762&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85014840762&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85014840762", "dc:identifier"=>"SCOPUS_ID:85014840762", "eid"=>"2-s2.0-85014840762", "dc:title"=>"Natural antimicrobial peptide complexes in the fighting of antibiotic resistant biofilms: Calliphora vicina medicinal maggots", "dc:creator"=>"Gordya N.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"12", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-03-01", "prism:coverDisplayDate"=>"March 2017", "prism:doi"=>"10.1371/journal.pone.0173559", "citedby-count"=>"19", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Saint Petersburg State University", "affiliation-city"=>"Saint Petersburg (ex Leningrad)", "affiliation-country"=>"Russian Federation"}], "pubmed-id"=>"28278280", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0173559", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Counter

  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"172", "xml_views"=>"6", "html_views"=>"421"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"40", "xml_views"=>"2", "html_views"=>"158"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"42", "xml_views"=>"2", "html_views"=>"134"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"100"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"44", "xml_views"=>"8", "html_views"=>"98"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"39", "xml_views"=>"3", "html_views"=>"101"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"68"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"105"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"194"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"323"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"43", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"10", "html_views"=>"44"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"17", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"7", "html_views"=>"37"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"43", "xml_views"=>"3", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"26", "xml_views"=>"2", "html_views"=>"41"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"42", "xml_views"=>"2", "html_views"=>"61"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"45", "xml_views"=>"2", "html_views"=>"37"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"33", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"40", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"55", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"14"}

PMC Usage Stats

  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"35", "full-text"=>"39", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"37", "full-text"=>"38", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"28", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"26", "full-text"=>"30", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"31", "full-text"=>"28", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"25", "full-text"=>"26", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"28", "full-text"=>"32", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"23", "full-text"=>"30", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"21", "full-text"=>"27", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"30", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"11", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
Loading … Spinner
There are currently no alerts