Antitumor activity of orally administered maitake α-glucan by stimulating antitumor immune response in murine tumor
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{"title"=>"Antitumor activity of orally administered maitake α-glucan by stimulating antitumor immune response in murine tumor", "type"=>"journal", "authors"=>[{"first_name"=>"Yuki", "last_name"=>"Masuda", "scopus_author_id"=>"35300147500"}, {"first_name"=>"Yoshiaki", "last_name"=>"Nakayama", "scopus_author_id"=>"7402057396"}, {"first_name"=>"Akihiro", "last_name"=>"Tanaka", "scopus_author_id"=>"57193564482"}, {"first_name"=>"Kenta", "last_name"=>"Naito", "scopus_author_id"=>"57193563981"}, {"first_name"=>"Morichika", "last_name"=>"Konishi", "scopus_author_id"=>"7201685732"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"28278221", "doi"=>"10.1371/journal.pone.0173621", "sgr"=>"85014899334", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85014899334", "issn"=>"19326203", "pui"=>"614718940"}, "id"=>"5d13fee4-1fba-3b3f-9fda-3cd5b9ed2c70", "abstract"=>"Maitake α-glucan, YM-2A, isolated from Grifola frondosa, has been characterized as a highly α-1,6-branched α-1,4 glucan. YM-2A has been shown to possess an anti-virus effect in mice; however, it does not directly inhibit growth of the virus in vitro, indicating that the anti-virus effect of YM-2A might be associated with modulation of the host immune system. In this study, we found that oral administration of YM-2A could inhibit tumor growth and improve survival rate in two distinct mouse models of colon-26 carcinoma and B16 melanoma. Orally administered YM-2A enhanced antitumor immune response by increasing INF-γ-expressing CD4+ and CD8+ cells in the spleen and INF-γ-expressing CD8+ cells in tumor-draining lymph nodes. In vitro study showed that YM-2A directly activated splenic CD11b+ myeloid cells, peritoneal macrophages and bone marrow-derived dendritic cells, but did not affect splenic CD11b- lymphocytes or colon-26 tumor cells. YM-2A is more slowly digested by pancreatic α-amylase than are amylopectin and rabbit liver glycogen, and orally administered YM-2A enhanced the expression of MHC class II and CD86 on dendritic cells and the expression of MHC class II on macrophages in Peyer's patches. Furthermore, in vitro stimulation of YM-2A increased the expression of pro-inflammatory cytokines in Peyer's patch CD11c+ cells. These results suggest that orally administered YM-2A can activate dendritic cells and macrophages in Peyer's patches, inducing systemic antitumor T-cell response. Thus, YM-2A might be a candidate for an oral therapeutic agent in cancer immunotherapy.", "link"=>"http://www.mendeley.com/research/antitumor-activity-orally-administered-maitake-%CE%B1glucan-stimulating-antitumor-immune-response-murine", "reader_count"=>7, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}

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