Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes
Publication Date
March 16, 2017
Authors
Colleen L. Doçi, Constantinos M. Mikelis, Juan Luis Callejas Valera, Karina K. Hansen, et al
Volume
12
Issue
3
Pages
e0173692
DOI
https://dx.plos.org/10.1371/journal.pone.0173692
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0173692
Scopus
85015703964
Mendeley
http://www.mendeley.com/research/epidermal-loss-g%CE%B1q-confers-migratory-differentiation-defect-keratinocytes
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Mendeley | Further Information

{"title"=>"Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes", "type"=>"journal", "authors"=>[{"first_name"=>"Colleen L.", "last_name"=>"Doçi", "scopus_author_id"=>"36503739000"}, {"first_name"=>"Constantinos M.", "last_name"=>"Mikelis", "scopus_author_id"=>"23061536400"}, {"first_name"=>"Juan Luis", "last_name"=>"Callejas-Valera", "scopus_author_id"=>"8853687600"}, {"first_name"=>"Karina K.", "last_name"=>"Hansen", "scopus_author_id"=>"55357921600"}, {"first_name"=>"Alfredo A.", "last_name"=>"Molinolo", "scopus_author_id"=>"7004099154"}, {"first_name"=>"Asuka", "last_name"=>"Inoue", "scopus_author_id"=>"8358533700"}, {"first_name"=>"Stefan", "last_name"=>"Offermanns", "scopus_author_id"=>"7005577974"}, {"first_name"=>"J. Silvio", "last_name"=>"Gutkind", "scopus_author_id"=>"7102457411"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "sgr"=>"85015703964", "doi"=>"10.1371/journal.pone.0173692", "isbn"=>"1111111111", "pmid"=>"28301547", "scopus"=>"2-s2.0-85015703964", "pui"=>"614831727"}, "id"=>"5fb5a695-8d7f-3367-a278-4179526bf241", "abstract"=>"G-protein oupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pathologic conditions. Two members of the G protein family, Gα q and Gα 11 , activate one of the main GPCR pathways and function as oncogenes by integrating mitogen-stimulated signaling cascades that are active under malignant conditions. Recently, it has been shown that targeted deletion of Gα 11 and Gα q from endothelial cells impairs the Rho-mediated formation of focal adherens junctions, suggesting that Gα 11/q signaling may also play a significant role in cytoskeletal-mediated cellular responses in epithelial cells. Indeed, combined deletion of Gα 11 and Gα q confers a significant migratory defect in keratinocytes that delays cutaneous wound healing in an in vivo setting. This delay can be attributed to a defect during the reepithelialization phase due to significantly attenuated migratory capacity of Gα q -null keratinocytes under combined Gα 11 deficiency. In fact, cells lacking Gα 11/q demonstrate a severely reduced ability to respond to mitogenic and migratory signals in the microenvironment, leading to inappropriate and premature terminal differentiation. These results suggest that Gα 11/q signaling pathways may be critical for integrating mitogenic signals and cytoskeletal function to achieve normal physiological responses. Emergence of a malignant phenotype may therefore arise from both under- and overexpression of Gα 11/q signaling, implicating its upstream regulation as a potential therapeutic target in a host of pathologic conditions.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.", "link"=>"http://www.mendeley.com/research/epidermal-loss-g%CE%B1q-confers-migratory-differentiation-defect-keratinocytes", "reader_count"=>8, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>4, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>4, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Italy"=>1}, "group_count"=>0}

Scopus | Further Information

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