The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stage-dependent manner
Publication Date
March 20, 2017
Authors
Kazushige Ota, Kit I. Tong, Kouichiro Goto, Shuta Tomida, et al
Volume
12
Issue
3
Pages
e0173713
DOI
https://dx.plos.org/10.1371/journal.pone.0173713
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0173713
Scopus
85015851118
Mendeley
http://www.mendeley.com/research/h3k27-demethylase-utx-regulates-adipogenesis-differentiation-stagedependent-manner
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Mendeley | Further Information

{"title"=>"The H3K27 demethylase, Utx, regulates adipogenesis in a differentiation stagedependent manner", "type"=>"journal", "authors"=>[{"first_name"=>"Kazushige", "last_name"=>"Ota", "scopus_author_id"=>"57191445142"}, {"first_name"=>"Kit I.", "last_name"=>"Tong", "scopus_author_id"=>"7102473510"}, {"first_name"=>"Kouichiro", "last_name"=>"Goto", "scopus_author_id"=>"7403195476"}, {"first_name"=>"Shuta", "last_name"=>"Tomida", "scopus_author_id"=>"7004352558"}, {"first_name"=>"Akiyoshi", "last_name"=>"Komuro", "scopus_author_id"=>"57191443304"}, {"first_name"=>"Zhong", "last_name"=>"Wang", "scopus_author_id"=>"55719623500"}, {"first_name"=>"Kazuto", "last_name"=>"Nishio", "scopus_author_id"=>"7202416406"}, {"first_name"=>"Hitoshi", "last_name"=>"Okada", "scopus_author_id"=>"7403733310"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-85015851118", "pmid"=>"28319137", "sgr"=>"85015851118", "doi"=>"10.1371/journal.pone.0173713", "pui"=>"614882517", "isbn"=>"1111111111"}, "id"=>"cc6fe985-f6d8-3802-beac-5f82456e68ec", "abstract"=>"Understanding the molecular mechanisms that drive adipogenesis is important in developing new treatments for obesity and diabetes. Epigenetic regulations determine the capacity of adipogenesis. In this study, we examined the role of a histone H3 lysine 27 demethylase, the ubiquitously transcribed tetratricopeptide repeat protein on the X chromosome (Utx), in the differentiation of mouse embryonic stem cells (mESCs) to adipocytes. Using gene trapping, we examined Utx-deficient male mESCs to determine whether loss of Utx would enhance or inhibit the differentiation of mESCs to adipocytes. Utx-deficient mESCs showed diminished potential to differentiate to adipocytes compared to that of controls. In contrast, Utx-deficient preadipocytes showed enhanced differentiation to adipocytes. Microarray analyses indicated that the β-catenin/c-Myc signaling pathway was differentially regulated in Utx-deficient cells during adipocyte differentiation. Therefore, our data suggest that Utx governs adipogenesis by regulating c-Myc in a differentiation stage-specific manner and that targeting the Utx signaling pathway could be beneficial for the treatment of obesity, diabetes, and congenital utx-deficiency disorders.", "link"=>"http://www.mendeley.com/research/h3k27-demethylase-utx-regulates-adipogenesis-differentiation-stagedependent-manner", "reader_count"=>10, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Master"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Master"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "group_count"=>1}

Scopus | Further Information

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