The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice
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{"title"=>"The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice", "type"=>"journal", "authors"=>[{"first_name"=>"Fengwei", "last_name"=>"Tian", "scopus_author_id"=>"19337981000"}, {"first_name"=>"Leilei", "last_name"=>"Yu", "scopus_author_id"=>"56510578800"}, {"first_name"=>"Qixiao", "last_name"=>"Zhai", "scopus_author_id"=>"55241436100"}, {"first_name"=>"Yue", "last_name"=>"Xiao", "scopus_author_id"=>"56457025100"}, {"first_name"=>"Ying", "last_name"=>"Shi", "scopus_author_id"=>"57193850813"}, {"first_name"=>"Jinchi", "last_name"=>"Jiang", "scopus_author_id"=>"57193843749"}, {"first_name"=>"Xiaoming", "last_name"=>"Liu", "scopus_author_id"=>"35262609800"}, {"first_name"=>"Jianxin", "last_name"=>"Zhao", "scopus_author_id"=>"7410309839"}, {"first_name"=>"Hao", "last_name"=>"Zhang", "scopus_author_id"=>"56311723200"}, {"first_name"=>"Wei", "last_name"=>"Chen", "scopus_author_id"=>"56388884500"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85017159545", "doi"=>"10.1371/journal.pone.0175398", "pui"=>"615215930", "scopus"=>"2-s2.0-85017159545", "issn"=>"19326203"}, "id"=>"4e689c4e-4872-3fef-ace5-124b503d0a2a", "abstract"=>"© 2017 Tian et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Our previous study found that Lactobacillus plantarum CCFM639 had the ability to alleviate acute aluminum (Al) toxicity when the strain was introduced simultaneously with Al exposure. This research was designed to elucidate the therapeutic effects of living and dead L plantarum CCFM639 against chronic Al toxicity and to gain insight into the protection modes of this strain. Animals were assigned into control, Al only, Al + living CCFM639, and Al + dead CCFM639 groups. The Al exposure model was established by drinking water for the first 4 weeks. The strain was given after Al exposure by oral gavage at 10 9 colony-forming units once per day for 12 weeks. The results show that the Al binding ability of dead CCFM639 was similar to that of living CCFM639 in vitro. The ingestion of living or dead CCFM639 has similar effects on levels of Al and trace element in tissues, but living strains led to more significant amelioration of oxidative stress and improvement of memory deficits in Al-exposed mice. In conclusion, in addition to intestinal Al sequestration, CCFM639 treatment offers direct protection against chronic Al toxicity by alleviation of oxidative stress. Therefore, L. plantarum CCFM639 has a potential as dietary supplement ingredient that provides protection against Al-induced injury.", "link"=>"http://www.mendeley.com/research/therapeutic-protection-living-dead-lactobacillus-strain-against-aluminuminduced-brain-liver-injuries", "reader_count"=>3, "reader_count_by_academic_status"=>{"Student > Ph. D. Student"=>2, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Student > Ph. D. Student"=>2, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Environmental Science"=>{"Environmental Science"=>1}}, "group_count"=>0}

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