The effects of immune protein CD3ζ development and degeneration of retinal neurons after optic nerve injury
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Mendeley | Further Information

{"title"=>"The effects of immune protein CD3ζ development and degeneration of retinal neurons after optic nerve injury", "type"=>"journal", "authors"=>[{"first_name"=>"Tao", "last_name"=>"He", "scopus_author_id"=>"57194140632"}, {"first_name"=>"Xavier", "last_name"=>"Mortensen", "scopus_author_id"=>"57194136068"}, {"first_name"=>"Ping", "last_name"=>"Wang", "scopus_author_id"=>"55718505000"}, {"first_name"=>"Ning", "last_name"=>"Tian", "scopus_author_id"=>"7006141160"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"615655362", "sgr"=>"85018842050", "doi"=>"10.1371/journal.pone.0175522", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85018842050"}, "id"=>"54fd4ae8-db9b-34a7-8497-cca466a38b5f", "abstract"=>"Major histocompatibility complex (MHC) class I molecules and their receptors play fundamental roles in neuronal death during diseases. T-cell receptors (TCR) function as MHCI receptor on T-cells and both MHCI and a key component of TCR, CD3ζ, are expressed by mouse retinal ganglion cells (RGCs) and displaced amacrine cells. Mutation of these molecules compromises the development of RGCs. We investigated whether CD3ζ regulates the development and degeneration of amacrine cells after RGC death. Surprisingly, mutation of CD3ζ not only impairs the proper development of amacrine cells expressing CD3ζ but also those not expressing CD3ζ. In contrast to effects of MHCI and its receptor, PirB, on other neurons, mutation of CD3ζ has no effect on RGC death and starburst amacrine cells degeneration after optic nerve crush. Thus, unlike MHCI and PirB, CD3ζ regulates the development of RGCs and amacrine cells but not their degeneration after optic nerve crush.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.", "link"=>"http://www.mendeley.com/research/effects-immune-protein-cd3%CE%B6-development-degeneration-retinal-neurons-after-optic-nerve-injury", "reader_count"=>3, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Researcher"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Researcher"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}}, "reader_count_by_country"=>{"France"=>1}, "group_count"=>1}

Scopus | Further Information

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