Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish
Publication Date
May 02, 2017
Authors
Michael J. Carvan Iii, Thomas A. Kalluvila, Rebekah H. Klingler, Jeremy K. Larson, et al
Volume
12
Issue
5
Pages
e0176155
DOI
https://dx.plos.org/10.1371/journal.pone.0176155
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0176155
Scopus
85018954867
Mendeley
http://www.mendeley.com/research/mercuryinduced-epigenetic-transgenerational-inheritance-abnormal-neurobehavior-correlated-sperm-epim
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Mendeley | Further Information

{"title"=>"Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish", "type"=>"journal", "authors"=>[{"first_name"=>"Michael J.", "last_name"=>"Carvan", "scopus_author_id"=>"6603051210"}, {"first_name"=>"Thomas A.", "last_name"=>"Kalluvila", "scopus_author_id"=>"57194168595"}, {"first_name"=>"Rebekah H.", "last_name"=>"Klingler", "scopus_author_id"=>"56029165500"}, {"first_name"=>"Jeremy K.", "last_name"=>"Larson", "scopus_author_id"=>"55808248500"}, {"first_name"=>"Matthew", "last_name"=>"Pickens", "scopus_author_id"=>"57194167873"}, {"first_name"=>"Francisco X.", "last_name"=>"Mora-Zamorano", "scopus_author_id"=>"57189035053"}, {"first_name"=>"Victoria P.", "last_name"=>"Connaughton", "scopus_author_id"=>"7004252790"}, {"first_name"=>"Ingrid", "last_name"=>"Sadler-Riggleman", "scopus_author_id"=>"6506459425"}, {"first_name"=>"Daniel", "last_name"=>"Beck", "scopus_author_id"=>"57193171281"}, {"first_name"=>"Michael K.", "last_name"=>"Skinner", "scopus_author_id"=>"7202488893"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85018954867", "pmid"=>"28464002", "pui"=>"615804110", "issn"=>"19326203", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85018954867", "doi"=>"10.1371/journal.pone.0176155"}, "id"=>"6fa703e3-6346-37df-8ab3-21b715485eb2", "abstract"=>"Methylmercury (MeHg) is a ubiquitous environmental neurotoxicant, with human exposures predominantly resulting from fish consumption. Developmental exposure of zebrafish to MeHg is known to alter their neurobehavior. The current study investigated the direct exposure and transgenerational effects of MeHg, at tissue doses similar to those detected in exposed human populations, on sperm epimutations (i.e., differential DNA methylation regions [DMRs]) and neurobehavior (i.e., visual startle and spontaneous locomotion) in zebrafish, an established human health model. F0 generation embryos were exposed to MeHg (0, 1, 3, 10, 30, and 100 nM) for 24 hours ex vivo. F0 generation control and MeHg-exposed lineages were reared to adults and bred to yield the F1 generation, which was subsequently bred to the F2 generation. Direct exposure (F0 generation) and transgenerational actions (F2 generation) were then evaluated. Hyperactivity and visual deficit were observed in the unexposed descendants (F2 generation) of the MeHg-exposed lineage compared to control. An increase in F2 generation sperm epimutations was observed relative to the F0 generation. Investigation of the DMRs in the F2 generation MeHg-exposed lineage sperm revealed associated genes in the neuroactive ligand-receptor interaction and actin-cytoskeleton pathways being effected, which correlate to the observed neurobehavioral phenotypes. Developmental MeHg-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in F2 generation adult zebrafish. Therefore, mercury can promote the epigenetic transgenerational inheritance of disease in zebrafish, which significantly impacts its environmental health considerations in all species including humans.", "link"=>"http://www.mendeley.com/research/mercuryinduced-epigenetic-transgenerational-inheritance-abnormal-neurobehavior-correlated-sperm-epim", "reader_count"=>32, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Researcher"=>1, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>4, "Professor > Associate Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Researcher"=>1, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>4, "Professor > Associate Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>10, "Medicine and Dentistry"=>1, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>6, "Psychology"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>6}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>2}

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