A prognostic model for development of significant liver fibrosis in HIV-hepatitis C co-infection
Publication Date
May 03, 2017
Authors
Nasheed Moqueet, Cynthia Kanagaratham, M. John Gill, Mark Hull, et al
Volume
12
Issue
5
Pages
e0176282
DOI
https://dx.plos.org/10.1371/journal.pone.0176282
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0176282
Scopus
85018726151
Mendeley
http://www.mendeley.com/research/prognostic-model-development-significant-liver-fibrosis-hivhepatitis-c-coinfection
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Mendeley | Further Information

{"title"=>"A prognostic model for development of significant liver fibrosis in HIV-hepatitis C co-infection", "type"=>"journal", "authors"=>[{"first_name"=>"Nasheed", "last_name"=>"Moqueet", "scopus_author_id"=>"15923307900"}, {"first_name"=>"Cynthia", "last_name"=>"Kanagaratham", "scopus_author_id"=>"35336615300"}, {"first_name"=>"M. John", "last_name"=>"Gill", "scopus_author_id"=>"18344438700"}, {"first_name"=>"Mark", "last_name"=>"Hull", "scopus_author_id"=>"56942197200"}, {"first_name"=>"Sharon", "last_name"=>"Walmsley", "scopus_author_id"=>"7005495799"}, {"first_name"=>"Danuta", "last_name"=>"Radzioch", "scopus_author_id"=>"7007012582"}, {"first_name"=>"Sahar", "last_name"=>"Saeed", "scopus_author_id"=>"36244333200"}, {"first_name"=>"Robert W.", "last_name"=>"Platt", "scopus_author_id"=>"7102023546"}, {"first_name"=>"Marina B.", "last_name"=>"Klein", "scopus_author_id"=>"57192119756"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-85018726151", "sgr"=>"85018726151", "pui"=>"615847278", "isbn"=>"1932-6203", "pmid"=>"615847278", "doi"=>"10.1371/journal.pone.0176282"}, "id"=>"15a53d9b-6317-3973-a955-96393e079b4d", "abstract"=>"Background Liver fibrosis progresses rapidly in HIV-Hepatitis C virus (HCV) co-infected individuals partially due to heightened inflammation. Immune markers targeting stages of fibrogenesis could aid in prognosis of fibrosis. Methods A case-cohort study was nested in the prospective Canadian Co-infection Cohort (n = 1119). HCV RNA positive individuals without fibrosis, end-stage liver disease or chronic Hepatitis B at baseline (n = 679) were eligible. A random subcohort (n = 236) was selected from those eligible. Pro-fibrogenic markers and Interferon Lambda (IFNL) rs8099917 genotype were measured from first available sample in all fibrosis cases (APRI >= 1.5 during follow-up) and the subcohort. We used Cox proportional hazards and compared Model 1 (selected clinical predictors only) to Model 2 (Model 1 plus selected markers) for predicting 3-year risk of liver fibrosis using weighted Harrell's C and Net Reclassification Improvement indices. Results 113 individuals developed significant liver fibrosis over 1300 person-years (8.63 per 100 person-years 95% CI: 7.08, 10.60). Model 1 (age, sex, current alcohol use, HIV RNA, baseline APRI, HCV genotype) was nested in model 2, which also included IFNL genotype and IL-8, sICAM-1, RANTES, hsCRP, and sCD14. The C indexes (95% CI) for model 1 vs. model 2 were 0.720 (0.649, 0.791) and 0.756 (0.688, 0.825), respectively. Model 2 classified risk more appropriately (overall net reclassification improvement, p<=0.05). Conclusions Including IFNL genotype and inflammatory markers IL-8, sICAM-1, RANTES, hs-CRP, and sCD14 enabled better prediction of the 3-year risk of significant liver fibrosis over clinical predictors alone. Whether this modest improvement in prediction justifies their additional cost requires further cost-benefit analyses. Copyright © 2017 Moqueet et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.", "link"=>"http://www.mendeley.com/research/prognostic-model-development-significant-liver-fibrosis-hivhepatitis-c-coinfection", "reader_count"=>7, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Student > Ph. D. Student"=>1, "Other"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Student > Ph. D. Student"=>1, "Other"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Medicine and Dentistry"=>3, "Neuroscience"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>1}

Scopus | Further Information

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