Allogeneic pASC transplantation in humanized pigs attenuates cardiac remodeling post-myocardial infarction
Publication Date
April 27, 2017
Authors
Rafael Dariolli, Marcus V. Naghetini, Euclydes F. Marques, Celso K. Takimura, et al
Volume
12
Issue
4
Pages
e0176412
DOI
https://dx.plos.org/10.1371/journal.pone.0176412
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0176412
Scopus
85018239447
Mendeley
http://www.mendeley.com/research/allogeneic-pasc-transplantation-humanized-pigs-attenuates-cardiac-remodeling-postmyocardial-infarcti
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Mendeley | Further Information

{"title"=>"Allogeneic pASC transplantation in humanized pigs attenuates cardiac remodeling postmyocardial infarction", "type"=>"journal", "authors"=>[{"first_name"=>"Rafael", "last_name"=>"Dariolli", "scopus_author_id"=>"15073797300"}, {"first_name"=>"Marcus V.", "last_name"=>"Naghetini", "scopus_author_id"=>"57194013418"}, {"first_name"=>"Euclydes F.", "last_name"=>"Marques", "scopus_author_id"=>"57194015105"}, {"first_name"=>"Celso K.", "last_name"=>"Takimura", "scopus_author_id"=>"6506262196"}, {"first_name"=>"Leonardo S.", "last_name"=>"Jensen", "scopus_author_id"=>"57190609921"}, {"first_name"=>"Bianca", "last_name"=>"Kiers", "scopus_author_id"=>"57189658687"}, {"first_name"=>"Jeane M.", "last_name"=>"Tsutsui", "scopus_author_id"=>"7005849247"}, {"first_name"=>"Wilson", "last_name"=>"Mathias", "scopus_author_id"=>"7003279008"}, {"first_name"=>"Pedro A.", "last_name"=>"Lemos Neto", "scopus_author_id"=>"55924596700"}, {"first_name"=>"Jose E.", "last_name"=>"Krieger", "scopus_author_id"=>"7201508348"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0176412", "issn"=>"19326203", "sgr"=>"85018239447", "scopus"=>"2-s2.0-85018239447", "pui"=>"615714695", "pmid"=>"28448588", "isbn"=>"1111111111"}, "id"=>"23c91d02-6b40-37da-8f9f-9cf5fcb2e904", "abstract"=>"Cell therapy repair strategies using adult mesenchymal stromal cells have shown promising evidence to prevent cardiac deterioration in rodents even in the absence of robust differentiation of the cells into cardiomyocytes. We tested whether increasing doses of porcine adipose-tissue derived mesenchymal stem cells (pASCs) increase cardiac tissue perfusion in pigs post-myocardial infarction (MI) receiving angiotensin-converting-enzyme inhibitor (ACE inhibitors) and Beta-blockers similarly to patients. Female pigs were subjected to MI induction by sponge permanent occlusion of left circumflex coronary artery (LCx) generating approximately 10% of injured LV area with minimum hemodynamic impact. We assessed tissue perfusion by real time myocardial perfusion echocardiography (RTMPE) using commercial microbubbles before and following pASCs treatment. Four weeks after the occlusion of the left circumflex artery, we transplanted placebo or pASCs (1, 2 and 4x106 cells/Kg BW) into the myocardium. The highest dose of pASCs increased myocardial vessel number and blood flow in the border (56% and 3.7-fold, respectively) and in the remote area (54% and 3.9-fold, respectively) while the non-perfused scar area decreased (up to 38%). We also found an increase of immature collagen fibers, although the increase in total tissue collagen and types I and III was similar in all groups. Our results provide evidence that pASCs-induced stimulation of tissue perfusion and accumulation of immature collagen fibers attenuates adverse remodeling post-MI beyond the normal beneficial effects associated with ACE inhibition and beta-blockade.", "link"=>"http://www.mendeley.com/research/allogeneic-pasc-transplantation-humanized-pigs-attenuates-cardiac-remodeling-postmyocardial-infarcti", "reader_count"=>7, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Professor"=>2, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Professor"=>2, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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