Differential DNA methylation of MSI2 and its correlation with diabetic traits
Publication Date
May 24, 2017
Authors
Jae Pil Jeon, In Uk Koh, Nak Hyun Choi, Bong Jo Kim, et al
Volume
12
Issue
5
Pages
e0177406
DOI
https://dx.plos.org/10.1371/journal.pone.0177406
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0177406
Scopus
85019671835
Mendeley
http://www.mendeley.com/research/differential-dna-methylation-msi2-correlation-diabetic-traits
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Mendeley | Further Information

{"title"=>"Differential DNA methylation of MSI2 and its correlation with diabetic traits", "type"=>"journal", "authors"=>[{"first_name"=>"Jae Pil", "last_name"=>"Jeon", "scopus_author_id"=>"14023048100"}, {"first_name"=>"In Uk", "last_name"=>"Koh", "scopus_author_id"=>"34968132500"}, {"first_name"=>"Nak Hyun", "last_name"=>"Choi", "scopus_author_id"=>"57194242504"}, {"first_name"=>"Bong Jo", "last_name"=>"Kim", "scopus_author_id"=>"57034500800"}, {"first_name"=>"Bok Ghee", "last_name"=>"Han", "scopus_author_id"=>"34667807900"}, {"first_name"=>"Suman", "last_name"=>"Lee", "scopus_author_id"=>"57194240198"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"616340027", "pmid"=>"28542303", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0177406", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85019671835", "sgr"=>"85019671835"}, "id"=>"5499855b-cdcb-341d-97b3-5b45cbbad5d7", "abstract"=>"Differential DNA methylation with hyperglycemia is significantly associated with Type 2 Diabetes (T2D). Longtime extended exposure to high blood glucose levels can affect the epigenetic signatures in all organs. However, the relevance of the differential DNA methylation changes with hyperglycemia in blood with pancreatic islets remains unclear. We investigated differential DNA methylation in relation to glucose homeostasis based on the Oral Glucose Tolerance Test (OGTT) in a population-based cohort. We found a total of 382 differential methylation sites from blood DNA in hyperglycemia and type 2 diabetes subgroups using a longitudinal and cross-sectional approach. Among them, three CpG sites were overlapped; they were mapped to the MSI2 and CXXC4 genes. In a DNA methylation replication study done by pyrosequencing (n = 440), the CpG site of MSI2 were shown to have strong associations with the T2D group (p value = 2.20E-16). The differential methylation of MSI2 at chr17:55484635 was associated with diabetes-related traits, in particular with insulin sensitivity (QUICKI, p value = 2.20E-16) and resistance (HOMA-IR, p value = 1.177E-07). In human pancreatic islets, at the single-base resolution (using whole-genome bisulfite sequencing), the 292 CpG sites in the ±5kb at chr17:55484635 were found to be significantly hypo-methylated in donors with T2D (average decrease = 13.91%, 95% confidence interval (CI) = 4.18~ 17.06) as compared to controls, and methylation patterns differed by sex (-9.57%, CI = -16.76~ -6.89) and age (0.12%, CI = -11.17~ 3.77). Differential methylation of the MSI2 gene (chr17:55484635) in blood and islet cells is strongly related to hyperglycemia. Our findings suggest that epigenetic perturbation on the target site of MSI2 gene in circulating blood and pancreatic islets should represent or affect hyperglycemia. ", "link"=>"http://www.mendeley.com/research/differential-dna-methylation-msi2-correlation-diabetic-traits", "reader_count"=>4, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>1, "Student > Doctoral Student"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>1, "Student > Doctoral Student"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>1, "Environmental Science"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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