Mobile phone reminders and peer counseling improve adherence and treatment outcomes of patients on ART in Malaysia: A randomized clinical trial
Publication Date
May 16, 2017
Authors
Surajudeen Abiola Abdulrahman, Lekhraj Rampal, Faisal Ibrahim, Anuradha P. Radhakrishnan, et al
Volume
12
Issue
5
Pages
e0177698
DOI
https://dx.plos.org/10.1371/journal.pone.0177698
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0177698
Scopus
85019623034
Mendeley
http://www.mendeley.com/research/mobile-phone-reminders-peer-counseling-improve-adherence-treatment-outcomes-patients-art-malaysia-ra
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Mendeley | Further Information

{"title"=>"Mobile phone reminders and peer counseling improve adherence and treatment outcomes of patients on ART in Malaysia: A randomized clinical trial", "type"=>"journal", "authors"=>[{"first_name"=>"Surajudeen Abiola", "last_name"=>"Abdulrahman", "scopus_author_id"=>"57193744432"}, {"first_name"=>"Lekhraj", "last_name"=>"Rampal", "scopus_author_id"=>"6602797407"}, {"first_name"=>"Faisal", "last_name"=>"Ibrahim", "scopus_author_id"=>"56201328400"}, {"first_name"=>"Anuradha P.", "last_name"=>"Radhakrishnan", "scopus_author_id"=>"55754310700"}, {"first_name"=>"Hayati Kadir", "last_name"=>"Shahar", "scopus_author_id"=>"56755342900"}, {"first_name"=>"Norlijah", "last_name"=>"Othman", "scopus_author_id"=>"16031506800"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85019623034", "sgr"=>"85019623034", "doi"=>"10.1371/journal.pone.0177698", "pui"=>"616266698", "pmid"=>"28520768", "isbn"=>"1111111111", "issn"=>"19326203"}, "id"=>"d3d493cb-8c67-399a-a3e8-0164c7771e46", "abstract"=>"BACKGROUND Adherence to treatment remains the cornerstone of long term viral suppression and successful treatment outcomes among patients receiving Antiretroviral Therapy (ART). OBJECTIVE(S) Evaluate the effectiveness of mobile phone reminders and peer counseling in improving adherence and treatment outcomes among HIV positive patients on ART in Malaysia. METHODS A single-blind, parallel group RCT conducted in Hospital Sungai Buloh, Malaysia in which 242 adult Malaysian patients were randomized to intervention or control groups. Intervention consisted of a reminder module delivered through SMS and telephone call reminders by trained research assistants for 24 consecutive weeks (starting from date of ART initiation), in addition to adherence counseling at every clinic visit. The length of intended follow up for each patient was 6 months. Data on adherence behavior of patients was collected using specialized, pre-validated Adult AIDS Clinical Trial Group (AACTG) adherence questionnaires. Data on weight, clinical symptoms, CD4 count and viral load tests were also collected. Data was analyzed using SPSS version 22 and R software. Repeated measures ANOVA, Friedman's ANOVA and Multivariate regression models were used to evaluate efficacy of the intervention. RESULTS The response rate after 6 months follow up was 93%. There were no significant differences at baseline in gender, employment status, income distribution and residential location of respondents between the intervention and control group. After 6 months follow up, the mean adherence was significantly higher in the intervention group (95.7; 95% CI: 94.39-96.97) as compared to the control group (87.5; 95% CI: 86.14-88.81). The proportion of respondents who had Good (>95%) adherence was significantly higher in the intervention group (92.2%) compared to the control group (54.6%). A significantly lower frequency in missed appointments (14.0% vs 35.5%) (p = 0.001), lower viral load (p = 0.001), higher rise in CD4 count (p = 0.017), lower incidence of tuberculosis (p = 0.001) and OIs (p = 0.001) at 6 months follow up, was observed among patients in the intervention group. CONCLUSION Mobile phone reminders (SMS and telephone call reminders) and peer counseling are effective in improving adherence and treatment outcomes among HIV positive patients on ART in Malaysia. These findings may be of potential benefit for collaborative adherence planning between patients and health care providers at ART commencement.", "link"=>"http://www.mendeley.com/research/mobile-phone-reminders-peer-counseling-improve-adherence-treatment-outcomes-patients-art-malaysia-ra", "reader_count"=>62, "reader_count_by_academic_status"=>{"Unspecified"=>12, "Student > Doctoral Student"=>1, "Researcher"=>7, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>3, "Student > Master"=>16, "Other"=>5, "Student > Bachelor"=>8, "Lecturer"=>2, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>12, "Student > Doctoral Student"=>1, "Researcher"=>7, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>3, "Student > Master"=>16, "Other"=>5, "Student > Bachelor"=>8, "Lecturer"=>2, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>14, "Nursing and Health Professions"=>10, "Medicine and Dentistry"=>23, "Arts and Humanities"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>6, "Psychology"=>3, "Social Sciences"=>3, "Economics, Econometrics and Finance"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>23}, "Social Sciences"=>{"Social Sciences"=>3}, "Psychology"=>{"Psychology"=>3}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>10}, "Unspecified"=>{"Unspecified"=>14}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>6}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "group_count"=>11}

Scopus | Further Information

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