Defining the vaccination window for respiratory syncytial virus (RSV) using age-seroprevalence data for children in Kilifi, Kenya
Publication Date
May 22, 2017
Authors
Joyce U. Nyiro, Ivy K. Kombe, Charles J. Sande, James Kipkoech, et al
Volume
12
Issue
5
Pages
e0177803
DOI
https://dx.plos.org/10.1371/journal.pone.0177803
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0177803
Scopus
85019938676
Mendeley
http://www.mendeley.com/research/defining-vaccination-window-respiratory-syncytial-virus-rsv-using-ageseroprevalence-data-children-ki
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Mendeley | Further Information

{"title"=>"Defining the vaccination window for Respiratory syncytial virus (RSV) using ageseroprevalence data for children in Kilifi, Kenya", "type"=>"journal", "authors"=>[{"first_name"=>"Joyce U.", "last_name"=>"Nyiro", "scopus_author_id"=>"8860421400"}, {"first_name"=>"Ivy K.", "last_name"=>"Kombe", "scopus_author_id"=>"57194391574"}, {"first_name"=>"Charles J.", "last_name"=>"Sande", "scopus_author_id"=>"22942437800"}, {"first_name"=>"James", "last_name"=>"Kipkoech", "scopus_author_id"=>"56191207600"}, {"first_name"=>"Patience K.", "last_name"=>"Kiyuka", "scopus_author_id"=>"56538602400"}, {"first_name"=>"Clayton O.", "last_name"=>"Onyango", "scopus_author_id"=>"14039497700"}, {"first_name"=>"Patrick K.", "last_name"=>"Munywoki", "scopus_author_id"=>"26533067900"}, {"first_name"=>"Timothy M.", "last_name"=>"Kinyanjui", "scopus_author_id"=>"56805137100"}, {"first_name"=>"D. James", "last_name"=>"Nokes", "scopus_author_id"=>"7006232828"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "doi"=>"10.1371/journal.pone.0177803", "sgr"=>"85019938676", "scopus"=>"2-s2.0-85019938676", "isbn"=>"1111111111", "pmid"=>"28531224", "pui"=>"616310776"}, "id"=>"2637494a-b09c-3601-bc03-0707a7ec8b17", "abstract"=>"Background Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract disease in early life and a target for vaccine prevention. Data on the age-prevalence of RSV specific antibodies will inform on optimizing vaccine delivery. Methods Archived plasma samples were randomly selected within age strata from 960 children less than 145 months of age admitted to Kilifi County Hospital pediatric wards between 2007 and 2010. Samples were tested for antibodies to RSV using crude virus IgG ELISA. Seroprevalence (and 95% confidence intervals) was estimated as the proportion of children with specific antibodies above a defined cut-off level. Nested catalytic models were used to explore different assumptions on antibody dynamics and estimate the rates of decay of RSV specific maternal antibody and acquisition of infection with age, and the average age of infection. Results RSV specific antibody prevalence was 100% at age 0-<1month, declining rapidly over the first 6 months of life, followed by an increase in the second half of the first year of life and beyond. Seroprevalence was lowest throughout the age range 5–11 months; all children were seropositive beyond 3 years of age. The best fit model to the data yielded estimates for the rate of infection of 0.78/person/year (95% CI 0.65–0.97) and 1.69/person/year (95% CI 1.27–2.04) for ages 0-<1 year and 1-<12 years, respectively. The rate of loss of maternal antibodies was estimated as 2.54/year (95% CI 2.30–2.90), i.e. mean duration 4.7 months. The mean age at primary infection was estimated at 15 months (95% CI 13–18). Conclusions The rate of decay of maternal antibody prevalence and subsequent age-acquisition of infection are rapid, and the average age at primary infection early. The vaccination window is narrow, and suggests optimal targeting of vaccine to infants 5 months and above to achieve high seroconversion.", "link"=>"http://www.mendeley.com/research/defining-vaccination-window-respiratory-syncytial-virus-rsv-using-ageseroprevalence-data-children-ki", "reader_count"=>23, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Other"=>1, "Student > Master"=>2, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Other"=>1, "Student > Master"=>2, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Mathematics"=>2, "Medicine and Dentistry"=>8, "Agricultural and Biological Sciences"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>1}

Scopus | Further Information

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