Local cryotherapy improves adjuvant-induced arthritis through down-regulation of IL-6 / IL-17 pathway but independently of TNFα
Publication Date
July 31, 2017
Authors
Xavier Guillot, Hélène Martin, Stéphanie Seguin Py, Katy Maguin Gaté, et al
Volume
12
Issue
7
Pages
e0178668
DOI
https://dx.plos.org/10.1371/journal.pone.0178668
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0178668
Scopus
85026357242
Mendeley
http://www.mendeley.com/research/local-cryotherapy-improves-adjuvantinduced-arthritis-through-downregulation-il6-il17-pathway-indepen
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Mendeley | Further Information

{"title"=>"Local cryotherapy improves adjuvant-induced arthritis through down-regulation of IL-6 / IL-17 pathway but independently of TNFα", "type"=>"journal", "authors"=>[{"first_name"=>"Xavier", "last_name"=>"Guillot", "scopus_author_id"=>"6506344057"}, {"first_name"=>"Hélène", "last_name"=>"Martin", "scopus_author_id"=>"7401980909"}, {"first_name"=>"Stéphanie", "last_name"=>"Seguin-Py", "scopus_author_id"=>"36132131300"}, {"first_name"=>"Katy", "last_name"=>"Maguin-Gaté", "scopus_author_id"=>"36949121500"}, {"first_name"=>"Johnny", "last_name"=>"Moretto", "scopus_author_id"=>"57193223918"}, {"first_name"=>"Perle", "last_name"=>"Totoson", "scopus_author_id"=>"54418168100"}, {"first_name"=>"Daniel", "last_name"=>"Wendling", "scopus_author_id"=>"56201235400"}, {"first_name"=>"Céline", "last_name"=>"Demougeot", "scopus_author_id"=>"6603072529"}, {"first_name"=>"Nicolas", "last_name"=>"Tordi", "scopus_author_id"=>"6701530517"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-85026357242", "sgr"=>"85026357242", "pui"=>"617564254", "isbn"=>"1111111111", "pmid"=>"28759646", "doi"=>"10.1371/journal.pone.0178668"}, "id"=>"6e098d9c-534e-3473-998e-a705d53e08e0", "abstract"=>"OBJECTIVES: Local cryotherapy is widely and empirically used in the adjuvant setting in rheumatoid arthritis treatment, however its own therapeutic and anti-inflammatory effects are poorly characterized. We aimed to evaluate the effects of local cryotherapy on local and systemic inflammation in Adjuvant-induced arthritis, a murine model of rheumatoid arthritis. METHODS: The effects of mild hypothermia (30 degrees C for 2 hours) on cytokine protein levels (Multiplex/ELISA) were evaluated in vitro in cultured rat adjuvant-induced arthritis patellae. In vivo, local cryotherapy was applied twice a day for 14 days in arthritic rats (ice: n = 10, cold gas: n = 9, non-treated: n = 10). At day 24 after the induction of arthritis, cytokine expression levels were measured in grinded hind paws (Q-RT-PCR) and in the plasma (Multiplex/ELISA). RESULTS: In vitro, punctual mild hypothermia down-regulated IL-6 protein expression. In vivo, ice showed a better efficacy profile on the arthritis score and joint swelling and was better tolerated, while cold gas induced a biphasic response profile with initial, transient arthritis worsening. Local cryotherapy also exerted local and systemic anti-inflammatory effects, both at the gene and the protein levels: IL-6, IL-17A and IL-1beta gene expression levels were significantly down-regulated in hind paws. Both techniques decreased plasma IL-17A while ice decreased plasma IL-6 protein levels. By contrast, we observed no effect on local/systemic TNF-alpha pathway. CONCLUSIONS: We demonstrated for the first time that sub-chronically applied local cryotherapy (ice and cold gas) is an effective and well-tolerated treatment in adjuvant-induced arthritis. Furthermore, we provided novel insights into the cytokine pathways involved in Local cryotherapy's local and systemic anti-inflammatory effects, which were mainly IL-6/IL-17A-driven and TNF-alpha independent in this model.", "link"=>"http://www.mendeley.com/research/local-cryotherapy-improves-adjuvantinduced-arthritis-through-downregulation-il6-il17-pathway-indepen", "reader_count"=>9, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Student > Master"=>3, "Other"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Student > Master"=>3, "Other"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>6}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "group_count"=>0}

Scopus | Further Information

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