APNG as a prognostic marker in patients with glioblastoma
Publication Date
June 29, 2017
Authors
Sigurd Fosmark, Sofie Hellwege, Rikke H. Dahlrot, Kristian L. Jensen, et al
Volume
12
Issue
6
Pages
e0178693
DOI
https://dx.plos.org/10.1371/journal.pone.0178693
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0178693
Scopus
85021686149
Mendeley
http://www.mendeley.com/research/apng-prognostic-marker-patients-glioblastoma
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Mendeley | Further Information

{"title"=>"APNG as a prognostic marker in patients with glioblastoma", "type"=>"journal", "authors"=>[{"first_name"=>"Sigurd", "last_name"=>"Fosmark", "scopus_author_id"=>"56607221900"}, {"first_name"=>"Sofie", "last_name"=>"Hellwege", "scopus_author_id"=>"56607354200"}, {"first_name"=>"Rikke H.", "last_name"=>"Dahlrot", "scopus_author_id"=>"55509548100"}, {"first_name"=>"Kristian L.", "last_name"=>"Jensen", "scopus_author_id"=>"57191624368"}, {"first_name"=>"Helene", "last_name"=>"Derand", "scopus_author_id"=>"57194683321"}, {"first_name"=>"Jesper", "last_name"=>"Lohse", "scopus_author_id"=>"7003323316"}, {"first_name"=>"Mia D.", "last_name"=>"Sørensen", "scopus_author_id"=>"56606734400"}, {"first_name"=>"Steinbjørn", "last_name"=>"Hansen", "scopus_author_id"=>"55435372800"}, {"first_name"=>"Bjarne W.", "last_name"=>"Kristensen", "scopus_author_id"=>"7101853240"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-85021686149", "sgr"=>"85021686149", "pui"=>"617004454", "isbn"=>"1111111111", "pmid"=>"28662073", "doi"=>"10.1371/journal.pone.0178693"}, "id"=>"2bbfa8d1-2808-39c6-ae49-4dab01d5475c", "abstract"=>"AIM Expression of the base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG) has been correlated to temozolomide resistance. Our aim was to evaluate the prognostic value of APNG in a population-based cohort with 242 gliomas including 185 glioblastomas (GBMs). Cellular heterogeneity of GBMs was taken into account by excluding APNG expression in non-tumor cells from the analysis. METHODS APNG expression was evaluated using automated image analysis and a novel quantitative immunohistochemical (IHC) assay (qIHC), where APNG protein expression was evaluated through countable dots. Non-tumor cells were excluded using an IHC/qIHC double-staining. For verification, APNG was measured by a quantitative double-immunofluorescence (IF) assay. As validation APNG mRNA expression was evaluated using independent TCGA data. RESULTS Using qIHC, high levels of APNG were associated with better overall survival (OS) in univariate (HR = 0.50; P < 0.001) and multivariate analysis (HR = 0.53; P = 0.001). Patients with methylated MGMT promoters and high APNG expression demonstrated better OS, than patients with methylated MGMT promoters and low APNG expression (HR = 0.59; P = 0.08). Retesting the cohort using IF showed similar results in both univariate (HR = 0.61; P = 0.002) and multivariate analysis (HR = 0.81; P = 0.2). The results were supported by data from the TCGA database. CONCLUSIONS Using two different assays combined with quantitative image analysis excluding non-tumour cells, APNG was an independent prognostic factor among patients with a methylated MGMT promoter. We expect that APNG qIHC can potentially identify GBM patients who will not benefit from treatment with temozolomide.", "link"=>"http://www.mendeley.com/research/apng-prognostic-marker-patients-glioblastoma", "reader_count"=>9, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Researcher"=>1, "Student > Ph. D. Student"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Researcher"=>1, "Student > Ph. D. Student"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemical Engineering"=>1, "Computer Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "group_count"=>0}

Scopus | Further Information

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