18F-FDG silicon photomultiplier PET/CT: A pilot study comparing semi-quantitative measurements with standard PET/CT
Publication Date
June 05, 2017
Authors
Lucia Baratto, Sonya Young Park, Negin Hatami, Guido Davidzon, et al
Volume
12
Issue
6
Pages
e0178936
DOI
https://dx.plos.org/10.1371/journal.pone.0178936
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0178936
Scopus
85020438376
Mendeley
http://www.mendeley.com/research/18ffdg-silicon-photomultiplier-petct-pilot-study-comparing-semiquantitative-measurements-standard-pe
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Mendeley | Further Information

{"title"=>"18F-FDG silicon photomultiplier PET/CT: A pilot study comparing semi-quantitative measurements with standard PET/CT", "type"=>"journal", "authors"=>[{"first_name"=>"Lucia", "last_name"=>"Baratto", "scopus_author_id"=>"57192982807"}, {"first_name"=>"Sonya Young", "last_name"=>"Park", "scopus_author_id"=>"57194494027"}, {"first_name"=>"Negin", "last_name"=>"Hatami", "scopus_author_id"=>"57195738151"}, {"first_name"=>"Guido", "last_name"=>"Davidzon", "scopus_author_id"=>"36950010500"}, {"first_name"=>"Shyam", "last_name"=>"Srinivas", "scopus_author_id"=>"7101841316"}, {"first_name"=>"Sanjiv Sam", "last_name"=>"Gambhir", "scopus_author_id"=>"7101904349"}, {"first_name"=>"Andrei", "last_name"=>"Iagaru", "scopus_author_id"=>"14325013500"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85020438376", "pui"=>"616630506", "scopus"=>"2-s2.0-85020438376", "issn"=>"19326203", "pmid"=>"28582472", "doi"=>"10.1371/journal.pone.0178936"}, "id"=>"ce4f2fce-29e3-3e26-a907-40737f6d712c", "abstract"=>"PURPOSE To evaluate if the new Discovery Molecular Insights (DMI) PET/CT scanner provides equivalent results compared to the standard of care PET/CT scanners (GE Discovery 600 or GE Discovery 690) used in our clinic and to explore any possible differences in semi-quantitative measurements. METHODS The local Institutional Review Board approved the protocol and written informed consent was obtained from each patient. Between September and November 2016, 50 patients underwent a single 18F-FDG injection and two scans: the clinical standard PET/CT followed immediately by the DMI PET/CT scan. We measured SUVmax and SUVmean of different background organs and up to four lesions per patient from data acquired using both scanners. RESULTS DMI PET/CT identified all the 107 lesions detected by standard PET/CT scanners, as well as additional 37 areas of focal increased 18F-FDG uptake. The SUVmax values for all 107 lesions ranged 1.2 to 14.6 (mean ± SD: 2.8 ± 2.8), higher on DMI PET/CT compared with standard of care PET/CT. The mean lesion:aortic arch SUVmax ratio and mean lesion:liver SUVmax ratio were 0.2-15.2 (mean ± SD: 3.2 ± 2.6) and 0.2-8.5 (mean ± SD: 1.9 ± 1.4) respectively, higher on DMI PET/CT than standard PET/CT. These differences were statistically significant (P value < 0.0001) and not correlated to the delay in acquisition of DMI PET data (P < 0.0001). CONCLUSIONS Our study shows high performance of the new DMI PET/CT scanner. This may have a significant role in diagnosing and staging disease, as well as for assessing and monitoring responses to therapies.", "link"=>"http://www.mendeley.com/research/18ffdg-silicon-photomultiplier-petct-pilot-study-comparing-semiquantitative-measurements-standard-pe", "reader_count"=>1, "reader_count_by_academic_status"=>{"Other"=>1}, "reader_count_by_user_role"=>{"Other"=>1}, "reader_count_by_subject_area"=>{"Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Neuroscience"=>{"Neuroscience"=>1}}, "group_count"=>0}

Scopus | Further Information

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