Association between circulating fibroblast growth factor 21 and mortality in end-stage renal disease
Publication Date
June 05, 2017
Journal
PLOS ONE
Authors
Marina Kohara, Takahiro Masuda, Kazuhiro Shiizaki, Tetsu Akimoto, et al
Volume
12
Issue
6
Pages
e0178971
DOI
https://dx.plos.org/10.1371/journal.pone.0178971
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0178971
Scopus
85020461037
Mendeley
http://www.mendeley.com/research/association-between-circulating-fibroblast-growth-factor-21-mortality-endstage-renal-disease
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Mendeley | Further Information

{"title"=>"Association between circulating fibroblast growth factor 21 and mortality in end-stage renal disease", "type"=>"journal", "authors"=>[{"first_name"=>"Marina", "last_name"=>"Kohara", "scopus_author_id"=>"57188816210"}, {"first_name"=>"Takahiro", "last_name"=>"Masuda", "scopus_author_id"=>"36896502400"}, {"first_name"=>"Kazuhiro", "last_name"=>"Shiizaki", "scopus_author_id"=>"6602447193"}, {"first_name"=>"Tetsu", "last_name"=>"Akimoto", "scopus_author_id"=>"7101694663"}, {"first_name"=>"Yuko", "last_name"=>"Watanabe", "scopus_author_id"=>"55710192000"}, {"first_name"=>"Sumiko", "last_name"=>"Honma", "scopus_author_id"=>"18934994300"}, {"first_name"=>"Chuji", "last_name"=>"Sekiguchi", "scopus_author_id"=>"57191378969"}, {"first_name"=>"Yasuharu", "last_name"=>"Miyazawa", "scopus_author_id"=>"57191381017"}, {"first_name"=>"Eiji", "last_name"=>"Kusano", "scopus_author_id"=>"7103337858"}, {"first_name"=>"Yoshinobu", "last_name"=>"Kanda", "scopus_author_id"=>"7203007686"}, {"first_name"=>"Yasushi", "last_name"=>"Asano", "scopus_author_id"=>"7401729186"}, {"first_name"=>"Makoto", "last_name"=>"Kuro-O", "scopus_author_id"=>"7006606065"}, {"first_name"=>"Daisuke", "last_name"=>"Nagata", "scopus_author_id"=>"20935586300"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"616630501", "pmid"=>"28582462", "doi"=>"10.1371/journal.pone.0178971", "issn"=>"19326203", "scopus"=>"2-s2.0-85020461037", "sgr"=>"85020461037"}, "id"=>"6fbf6f9d-1993-316d-a65e-db1baa227256", "abstract"=>"Fibroblast growth factor 21 (FGF21) is an endocrine factor that regulates glucose and lipid metabolism. Circulating FGF21 predicts cardiovascular events and mortality in type 2 diabetes mellitus, including early-stage chronic kidney disease, but its impact on clinical outcomes in end-stage renal disease (ESRD) patients remains unclear. This study enrolled 90 ESRD patients receiving chronic hemodialysis who were categorized into low- and high-FGF21 groups by the median value. We investigated the association between circulating FGF21 levels and the cardiovascular event and mortality during a median follow-up period of 64 months. A Kaplan-Meier analysis showed that the mortality rate was significantly higher in the high-FGF21 group than in the low-FGF21 group (28.3% vs. 9.1%, log-rank, P = 0.034), while the rate of cardiovascular events did not significantly differ between the two groups (30.4% vs. 22.7%, log-rank, P = 0.312). In multivariable Cox models adjusted a high FGF21 level was an independent predictor of all-cause mortality (hazard ratio: 3.98; 95% confidence interval: 1.39-14.27, P = 0.009). Higher circulating FGF21 levels were associated with a high mortality rate, but not cardiovascular events in patient with ESRD, suggesting that circulating FGF21 levels serve as a predictive marker for mortality in these subjects.; ", "link"=>"http://www.mendeley.com/research/association-between-circulating-fibroblast-growth-factor-21-mortality-endstage-renal-disease", "reader_count"=>4, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Master"=>1, "Lecturer > Senior Lecturer"=>1, "Student > Ph. D. Student"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Master"=>1, "Lecturer > Senior Lecturer"=>1, "Student > Ph. D. Student"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>1, "Neuroscience"=>1, "Chemistry"=>1, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}}, "group_count"=>0}

Scopus | Further Information

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