Comparison between intra-articular ozone and placebo in the treatment of knee osteoarthritis: A randomized, double-blinded, placebo-controlled study
Publication Date
July 24, 2017
Authors
Carlos César Lopes De Jesus, Fânia Cristina Dos Santos, Luciana Maria Oliveira Bueno De Jesus, Iara Monteiro, et al
Volume
12
Issue
7
Pages
e0179185
DOI
https://dx.plos.org/10.1371/journal.pone.0179185
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0179185
Scopus
85025446362
Mendeley
http://www.mendeley.com/research/comparison-between-intraarticular-ozone-placebo-treatment-knee-osteoarthritis-randomized-doubleblind-5
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Mendeley | Further Information

{"title"=>"Comparison between intra-articular ozone and placebo in the treatment of knee osteoarthritis: A randomized, double-blinded, placebo-controlled study", "type"=>"journal", "authors"=>[{"first_name"=>"Carlos César", "last_name"=>"Lopes De Jesus", "scopus_author_id"=>"6504586996"}, {"first_name"=>"Fânia Cristina", "last_name"=>"Dos Santos", "scopus_author_id"=>"7005642486"}, {"first_name"=>"Luciana Maria Oliveira Bueno", "last_name"=>"De Jesus", "scopus_author_id"=>"57195108131"}, {"first_name"=>"Iara", "last_name"=>"Monteiro", "scopus_author_id"=>"6701448657"}, {"first_name"=>"Maria Sonia Sousa Castro", "last_name"=>"Sant’Ana", "scopus_author_id"=>"57195109846"}, {"first_name"=>"Virginia Fernandes Moça", "last_name"=>"Trevisani", "scopus_author_id"=>"6602273695"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"617460529", "sgr"=>"85025446362", "issn"=>"19326203", "pmid"=>"28738079", "scopus"=>"2-s2.0-85025446362", "doi"=>"10.1371/journal.pone.0179185", "isbn"=>"1111111111"}, "id"=>"7589efa0-cf76-30d2-b8c0-523c498f9560", "abstract"=>"OBJECTIVE The aim of the trial was to determine the effectiveness of oxygen-ozone injections on knee osteoarthritis concerning pain reduction, joint functional improvement, and quality of life. METHODS In this randomized, double-blinded, placebo controlled clinical trial, 98 patients with symptomatic knee osteoarthritis (OA) were randomized into two groups receiving intra-articular 20 μg/ml of ozone (OZ) or placebo (PBO) for 8 weeks. The efficacy outcomes for knee OA were the Visual Analogue Scale (VAS), Lequesne Index, Timed Up and Go Test (TUG Test), SF-36, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Geriatric Pain Measure (GPM). RESULTS After 8 weeks of treatment, ozone was more effective than the placebo: VAS [mean difference (MD) = 2.16, p < 0.003 (CI 95% 0.42-3.89)], GPM [MD = 18.94, p < 0.004 (CI 95% 3.43-34.44)], LEQ [MD = 4.05, p < 0.001 (CI 95% 1.10-7.00)], WOMAC (P) [median of diff = 9.999, p = 0.019 (CI 95% 0.000-15.000)], WOMAC (JS) [median of diff = 12.499, p < 0.001 (CI 95% 0.000-12.500)], WOMAC (PF) = [median of diff = 11.760, p = 0.003 (CI 95% 4.409-19.119)], TUG (no statistical difference) and SF-36 (FC) [(MD = -25.82, p < 0.001 (CI 95% 33.65-17.99)], SF-36 (PH) [MD = -40.82, p < 0.001 (CI 95% -54.48-27.17)], SF-36 (GSH) [MD = -3.38, p < 0.001 (CI 95% -4.83-1.93)], SF-36 (SA) [MD = 2.17, p < 0.001 (CI 95% -19.67-8.24), SF-36 (EA) [MD = -35.37, p < 0.001 (CI 95% -48.86-21.89)]. Adverse events occurred in 3 patients (2 in the placebo group and 1 in the ozone group) and included only puncture accidents. CONCLUSIONS The study confirms the efficacy of ozone concerning pain relief, functional improvement, and quality of life in patients with knee osteoarthritis. TRIAL REGISTRATION International Standard Randomized Controlled Trial Number Register ISRCTNR55861167.", "link"=>"http://www.mendeley.com/research/comparison-between-intraarticular-ozone-placebo-treatment-knee-osteoarthritis-randomized-doubleblind-5", "reader_count"=>17, "reader_count_by_academic_status"=>{"Unspecified"=>9, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>9, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>10, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>4, "Veterinary Science and Veterinary Medicine"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>10}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "group_count"=>2}

Scopus | Further Information

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