Prevention of mother-to-child transmission of HIV: Postpartum adherence to Option B+ until 18 months in Western Uganda
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Mendeley | Further Information

{"title"=>"Prevention of mother-to-child transmission of HIV: Postpartum adherence to Option B+ until 18 months in Western Uganda", "type"=>"journal", "authors"=>[{"first_name"=>"Sarah", "last_name"=>"Decker", "scopus_author_id"=>"56872487400"}, {"first_name"=>"Eva", "last_name"=>"Rempis", "scopus_author_id"=>"55633849500"}, {"first_name"=>"Alexandra", "last_name"=>"Schnack", "scopus_author_id"=>"56582257800"}, {"first_name"=>"Vera", "last_name"=>"Braun", "scopus_author_id"=>"56872491300"}, {"first_name"=>"John", "last_name"=>"Rubaihayo", "scopus_author_id"=>"37017677100"}, {"first_name"=>"Priscilla", "last_name"=>"Busingye", "scopus_author_id"=>"55353024500"}, {"first_name"=>"Nazarius Mbona", "last_name"=>"Tumwesigye", "scopus_author_id"=>"23061774900"}, {"first_name"=>"Gundel", "last_name"=>"Harms", "scopus_author_id"=>"7005891095"}, {"first_name"=>"Stefanie", "last_name"=>"Theuring", "scopus_author_id"=>"26428490100"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "doi"=>"10.1371/journal.pone.0179448", "sgr"=>"85021681166", "scopus"=>"2-s2.0-85021681166", "isbn"=>"1932-6203", "pmid"=>"28662036", "pui"=>"617004442"}, "id"=>"651555d5-9869-3b94-a40c-e3905929bac9", "abstract"=>"Since 2012, the WHO recommends Option B+ for the prevention of mother-to-child transmission of HIV. This approach entails the initiation of lifelong antiretroviral therapy in all HIV-positive pregnant women, also implying protection during breastfeeding for 12 months or longer. Research on long-term adherence to Option B+ throughout breastfeeding is scarce to date. Therefore, we conducted a prospective observational cohort study in Fort Portal, Western Uganda, to assess adherence to Option B+ until 18 months postpartum. In 2013, we recruited 67 HIV-positive, Option B+ enrolled women six weeks after giving birth and scheduled them for follow-up study visits after six, twelve and 18 months. Two adherence measures, self-reported drug intake and amount of drug refill visits, were combined to define adherence, and were assessed together with feeding information at all study visits. At six months postpartum, 51% of the enrolled women were considered to be adherent. Until twelve and 18 months postpartum, adherence for the respective follow-up interval decreased to 19% and 20.5% respectively. No woman was completely adherent until 18 months. At the same time, 76.5% of the women breastfed for ≥12 months. Drug adherence was associated with younger age (p<0.01), lower travel costs (p = 0.02), and lower number of previous deliveries (p = 0.04). Long-term adherence to Option B+ seems to be challenging. Considering that in our cohort, prolonged breastfeeding until ≥12 months was widely applied while postpartum adherence until the end of breastfeeding was poor, a potential risk of postpartum vertical transmission needs to be taken seriously into account for Option B+ implementation.", "link"=>"http://www.mendeley.com/research/prevention-mothertochild-transmission-hiv-postpartum-adherence-option-b-until-18-months-western-ugan", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>7, "Student > Bachelor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>7, "Student > Bachelor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Nursing and Health Professions"=>5, "Medicine and Dentistry"=>8, "Business, Management and Accounting"=>1, "Immunology and Microbiology"=>1, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>5}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>4}}, "group_count"=>0}

Scopus | Further Information

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