Risk of ischemic stroke after atrial fibrillation diagnosis: A national sample cohort
Publication Date
June 21, 2017
Authors
Mi Kyoung Son, Nam Kyoo Lim, Hyung Woo Kim & Hyun Young Park
Volume
12
Issue
6
Pages
e0179687
DOI
https://dx.plos.org/10.1371/journal.pone.0179687
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0179687
Scopus
85021206225
Mendeley
http://www.mendeley.com/research/risk-ischemic-stroke-after-atrial-fibrillation-diagnosis-national-sample-cohort-1
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Mendeley | Further Information

{"title"=>"Risk of ischemic stroke after atrial fibrillation diagnosis: A national sample cohort", "type"=>"journal", "authors"=>[{"first_name"=>"Mi Kyoung", "last_name"=>"Son"}, {"first_name"=>"Nam-Kyoo", "last_name"=>"Lim"}, {"first_name"=>"Hyung Woo", "last_name"=>"Kim"}, {"first_name"=>"Hyun-Young", "last_name"=>"Park"}], "year"=>2017, "source"=>"PLOS ONE", "identifiers"=>{"issn"=>"1932-6203", "pmid"=>"28636620", "doi"=>"10.1371/journal.pone.0179687", "isbn"=>"1111111111"}, "id"=>"a27dbd12-900d-316a-9b11-0382f5e2273a", "abstract"=>"Atrial fibrillation (AF) is a major risk factor for ischemic stroke and associated with a 5-fold higher risk of stroke. In this retrospective cohort study, the incidence of and risk factors for ischemic stroke in patients with AF were identified. All patients (≥30 years old) without previous stroke who were diagnosed with AF in 2007-2013 were selected from the National Health Insurance Service-National Sample Cohort. To identify factors that influenced ischemic stroke risk, Cox proportional hazard regression analysis was conducted. During a mean follow-up duration of 3.2 years, 1022 (9.6%) patients were diagnosed with ischemic stroke. The overall incidence rate of ischemic stroke was 30.8/1000 person-years. Of all the ischemic stroke that occurred during the follow-up period, 61.0% occurred within 1-year after AF diagnosis. Of the patients with CHA2DS2-VASc score of ≥2, only 13.6% were receiving warfarin therapy within 30 days after AF diagnosis. Relative to no antithrombotic therapy, warfarin treatment for >90 days before the index event (ischemic stroke in stroke patients and death/study end in non-stroke patients) associated with decreased ischemic stroke risk (Hazard Ratio = 0.41, 95%confidence intervals = 0.32-0.53). Heart failure, hypertension, and diabetes mellitus associated with greater ischemic stroke risk. AF patients in Korea had a higher ischemic stroke incidence rate than patients in other countries and ischemic stroke commonly occurred at early phase after AF diagnosis. Long-term (>90 days) continuous warfarin treatment may be beneficial for AF patients. However, warfarin treatment rates were very low. To prevent stroke, programs that actively detect AF and provide anticoagulation therapy are needed.", "link"=>"http://www.mendeley.com/research/risk-ischemic-stroke-after-atrial-fibrillation-diagnosis-national-sample-cohort-1", "reader_count"=>13, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Student > Doctoral Student"=>3, "Student > Postgraduate"=>4, "Student > Master"=>1, "Other"=>1, "Lecturer > Senior Lecturer"=>1, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Student > Doctoral Student"=>3, "Student > Postgraduate"=>4, "Student > Master"=>1, "Other"=>1, "Lecturer > Senior Lecturer"=>1, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Medicine and Dentistry"=>6, "Neuroscience"=>1, "Psychology"=>1, "Nursing and Health Professions"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>4}}, "group_count"=>2}

Scopus | Further Information

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