The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses
Publication Date
June 30, 2017
Authors
Elyse Kozlowski, Gregory A. Wasserman, Marcos Morgan, Dónal O’carroll, et al
Volume
12
Issue
6
Pages
e0179797
DOI
https://dx.plos.org/10.1371/journal.pone.0179797
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0179797
Scopus
85021679099
Mendeley
http://www.mendeley.com/research/rna-uridyltransferase-zcchc6-expressed-macrophages-impacts-innate-immune-responses
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Mendeley | Further Information

{"title"=>"The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses", "type"=>"journal", "authors"=>[{"first_name"=>"Elyse", "last_name"=>"Kozlowski", "scopus_author_id"=>"55513514100"}, {"first_name"=>"Gregory A.", "last_name"=>"Wasserman", "scopus_author_id"=>"7102233484"}, {"first_name"=>"Marcos", "last_name"=>"Morgan", "scopus_author_id"=>"57194680986"}, {"first_name"=>"Dónal", "last_name"=>"O’Carroll", "scopus_author_id"=>"57190132757"}, {"first_name"=>"Nora Guadalupe P.", "last_name"=>"Ramirez", "scopus_author_id"=>"56226656600"}, {"first_name"=>"Suryaram", "last_name"=>"Gummuluru", "scopus_author_id"=>"6603123131"}, {"first_name"=>"Jasmine Y.", "last_name"=>"Rah", "scopus_author_id"=>"57194690768"}, {"first_name"=>"Adam C.", "last_name"=>"Gower", "scopus_author_id"=>"7006264081"}, {"first_name"=>"Michael", "last_name"=>"Ieong", "scopus_author_id"=>"7003550368"}, {"first_name"=>"Lee J.", "last_name"=>"Quinton", "scopus_author_id"=>"6507679389"}, {"first_name"=>"Joseph P.", "last_name"=>"Mizgerd", "scopus_author_id"=>"6701489913"}, {"first_name"=>"Matthew R.", "last_name"=>"Jones", "scopus_author_id"=>"55700819900"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0179797", "issn"=>"19326203", "sgr"=>"85021679099", "scopus"=>"2-s2.0-85021679099", "pui"=>"617025208", "isbn"=>"1111111111", "pmid"=>"28665939"}, "id"=>"97f0411a-617e-3efd-aeca-eba543dded7e", "abstract"=>"Alveolar macrophages orchestrate pulmonary innate immunity and are essential for early immune surveillance and clearance of microorganisms in the airways. Inflammatory signaling must be sufficiently robust to promote host defense but limited enough to prevent excessive tissue injury. Macrophages in the lungs utilize multiple transcriptional and post-transcriptional mechanisms of inflammatory gene expression to delicately balance the elaboration of immune mediators. RNA terminal uridyltransferases (TUTs), including the closely homologous family members Zcchc6 (TUT7) and Zcchc11 (TUT4), have been implicated in the post-transcriptional regulation of inflammation from studies conducted in vitro. In vivo, we observed that Zcchc6 is expressed in mouse and human primary macrophages. Zcchc6-deficient mice are viable and born in Mendelian ratios and do not exhibit an observable spontaneous phenotype under basal conditions. Following an intratracheal challenge with S. pneumoniae, Zcchc6 deficiency led to a modest but significant increase in the expression of select cytokines including IL-6, CXCL1, and CXCL5. These findings were recapitulated in vitro whereby Zcchc6-deficient macrophages exhibited similar increases in cytokine expression due to bacterial stimulation. Although loss of Zcchc6 also led to increased neutrophil emigration to the airways during pneumonia, these responses were not sufficient to impact host defense against infection.", "link"=>"http://www.mendeley.com/research/rna-uridyltransferase-zcchc6-expressed-macrophages-impacts-innate-immune-responses", "reader_count"=>5, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>0}

Scopus | Further Information

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