Role of magnesium supplementation in the treatment of depression: A randomized clinical trial
Publication Date
June 27, 2017
Authors
Emily K. Tarleton, Benjamin Littenberg, Charles D. Mac Lean, Amanda G. Kennedy, et al
Volume
12
Issue
6
Pages
e0180067
DOI
https://dx.plos.org/10.1371/journal.pone.0180067
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0180067
Scopus
85021351913
Mendeley
http://www.mendeley.com/research/role-magnesium-supplementation-treatment-depression-randomized-clinical-trial
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Mendeley | Further Information

{"title"=>"Role of magnesium supplementation in the treatment of depression: A randomized clinical trial", "type"=>"journal", "authors"=>[{"first_name"=>"Emily K.", "last_name"=>"Tarleton", "scopus_author_id"=>"56625739600"}, {"first_name"=>"Benjamin", "last_name"=>"Littenberg", "scopus_author_id"=>"7005002340"}, {"first_name"=>"Charles D.", "last_name"=>"MacLean", "scopus_author_id"=>"7102972787"}, {"first_name"=>"Amanda G.", "last_name"=>"Kennedy", "scopus_author_id"=>"7401653801"}, {"first_name"=>"Christopher", "last_name"=>"Daley", "scopus_author_id"=>"54900684400"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85021351913", "sgr"=>"85021351913", "doi"=>"10.1371/journal.pone.0180067", "pui"=>"616972426", "pmid"=>"28654669", "isbn"=>"1111111111", "issn"=>"19326203"}, "id"=>"ab309fc4-5bfd-3319-bedf-3169f3ce92e1", "abstract"=>"Current treatment options for depression are limited by efficacy, cost, availability, side effects, and acceptability to patients. Several studies have looked at the association between magnesium and depression, yet its role in symptom management is unclear. The objective of this trial was to test whether supplementation with over-the-counter magnesium chloride improves symptoms of depression. An open-label, blocked, randomized, cross-over trial was carried out in outpatient primary care clinics on 126 adults (mean age 52; 38% male) diagnosed with and currently experiencing mild-to-moderate symptoms with Patient Health Questionnaire-9 (PHQ-9) scores of 5–19. The intervention was 6 weeks of active treatment (248 mg of elemental magnesium per day) compared to 6 weeks of control (no treatment). Assessments of depression symptoms were completed at bi-weekly phone calls. The primary outcome was the net difference in the change in depression symptoms from baseline to the end of each treatment period. Secondary outcomes included changes in anxiety symptoms as well as adherence to the supplement regimen, appearance of adverse effects, and intention to use magnesium supplements in the future. Between June 2015 and May 2016, 112 participants provided analyzable data. Consumption of magne-sium chloride for 6 weeks resulted in a clinically significant net improvement in PHQ-9 scores of -6.0 points (CI -7.9, -4.2; P<0.001) and net improvement in Generalized Anxiety Disorders-7 scores of -4.5 points (CI -6.6, -2.4; P<0.001). Average adherence was 83% by pill count. The supplements were well tolerated and 61% of participants reported they would use magnesium in the future. Similar effects were observed regardless of age, gender, baseline severity of depression, baseline magnesium level, or use of antidepressant treat-ments. Effects were observed within two weeks. Magnesium is effective for mild-to-moder-ate depression in adults. It works quickly and is well tolerated without the need for close monitoring for toxicity.", "link"=>"http://www.mendeley.com/research/role-magnesium-supplementation-treatment-depression-randomized-clinical-trial", "reader_count"=>53, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>8, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>4, "Student > Master"=>7, "Other"=>5, "Student > Bachelor"=>20, "Lecturer"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>8, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>4, "Student > Master"=>7, "Other"=>5, "Student > Bachelor"=>20, "Lecturer"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Agricultural and Biological Sciences"=>6, "Veterinary Science and Veterinary Medicine"=>1, "Computer Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Nursing and Health Professions"=>11, "Medicine and Dentistry"=>13, "Neuroscience"=>2, "Design"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Sports and Recreations"=>1, "Psychology"=>3, "Social Sciences"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Social Sciences"=>{"Social Sciences"=>4}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>3}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Design"=>{"Design"=>1}, "Neuroscience"=>{"Neuroscience"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>11}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>4}

Scopus | Further Information

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