Endotypes of difficult-to-control asthma in inner-city African American children
Publication Date
July 07, 2017
Authors
K. R. Brown, R. Z. Krouse, A. Calatroni, C. M. Visness, et al
Volume
12
Issue
7
Pages
e0180778
DOI
https://dx.plos.org/10.1371/journal.pone.0180778
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0180778
Scopus
85022335990
Mendeley
http://www.mendeley.com/research/endotypes-difficulttocontrol-asthma-innercity-african-american-children
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Mendeley | Further Information

{"title"=>"Endotypes of difficult-to-control asthma in inner-city African American children", "type"=>"journal", "authors"=>[{"first_name"=>"K. R.", "last_name"=>"Brown", "scopus_author_id"=>"57194797181"}, {"first_name"=>"R. Z.", "last_name"=>"Krouse", "scopus_author_id"=>"57189691377"}, {"first_name"=>"A.", "last_name"=>"Calatroni", "scopus_author_id"=>"12806277000"}, {"first_name"=>"C. M.", "last_name"=>"Visness", "scopus_author_id"=>"25947110000"}, {"first_name"=>"U.", "last_name"=>"Sivaprasad", "scopus_author_id"=>"36857632200"}, {"first_name"=>"C. M.", "last_name"=>"Kercsmar", "scopus_author_id"=>"7003621745"}, {"first_name"=>"E. C.", "last_name"=>"Matsui", "scopus_author_id"=>"7006545384"}, {"first_name"=>"J. B.", "last_name"=>"West", "scopus_author_id"=>"57192556076"}, {"first_name"=>"M. M.", "last_name"=>"Makhija", "scopus_author_id"=>"55273583100"}, {"first_name"=>"M. A.", "last_name"=>"Gill", "scopus_author_id"=>"7402770712"}, {"first_name"=>"H.", "last_name"=>"Kim", "scopus_author_id"=>"57194797812"}, {"first_name"=>"M.", "last_name"=>"Kattan", "scopus_author_id"=>"55778141016"}, {"first_name"=>"D.", "last_name"=>"Pillai", "scopus_author_id"=>"54940294200"}, {"first_name"=>"J. E.", "last_name"=>"Gern", "scopus_author_id"=>"14831290800"}, {"first_name"=>"W. W.", "last_name"=>"Busse", "scopus_author_id"=>"36044624500"}, {"first_name"=>"A.", "last_name"=>"Togias", "scopus_author_id"=>"7006101314"}, {"first_name"=>"A. H.", "last_name"=>"Liu", "scopus_author_id"=>"7402582215"}, {"first_name"=>"G. K.Khurana", "last_name"=>"Hershey", "scopus_author_id"=>"57108797400"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-85022335990", "sgr"=>"85022335990", "pui"=>"617202895", "isbn"=>"1111111111", "pmid"=>"28686637", "doi"=>"10.1371/journal.pone.0180778"}, "id"=>"71f7f9c1-7cca-37ce-9a2d-1e135bb71546", "abstract"=>"African Americans have higher rates of asthma prevalence, morbidity, and mortality in comparison with other racial groups. We sought to characterize endotypes of childhood asthma severity in African American patients in an inner-city pediatric asthma population. Baseline blood neutrophils, blood eosinophils, and 38 serum cytokine levels were measured in a sample of 235 asthmatic children (6–17 years) enrolled in the NIAID (National Institute of Allergy and Infectious Diseases)-sponsored Asthma Phenotypes in the Inner City (APIC) study (ICAC (Inner City Asthma Consortium)-19). Cytokines were quantified using a MILLIPLEX panel and analyzed on a Luminex analyzer. Patients were classified as Easy-to-Control or Difficult-to-Control based on the required dose of controller medications over one year of prospective management. A multivariate variable selection procedure was used to select cytokines associated with Difficult-to-Control versus Easy-to-Control asthma, adjusting for age, sex, blood eosinophils, and blood neutrophils. In inner-city African American children, 12 cytokines were significant predictors of Difficult-to-Control asthma (n = 235). CXCL-1, IL-5, IL-8, and IL-17A were positively associated with Difficult-to-Control asthma, while IL-4 and IL-13 were positively associated with Easy-to-Control asthma. Using likelihood ratio testing, it was observed that in addition to blood eosinophils and neutrophils, serum cytokines improved the fit of the model. In an inner-city pediatric population, serum cytokines significantly contributed to the definition of Difficult-to-Control asthma endotypes in African American children. Mixed responses characterized by T(H)2 (IL-5) and T(H)17-associated cytokines were associated with Difficult-to-Control asthma. Collectively, these data may contribute to risk stratification of Difficult-to-Control asthma in the African American population. ", "link"=>"http://www.mendeley.com/research/endotypes-difficulttocontrol-asthma-innercity-african-american-children", "reader_count"=>15, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Master"=>2, "Other"=>3, "Student > Bachelor"=>1, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Master"=>2, "Other"=>3, "Student > Bachelor"=>1, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>2, "Mathematics"=>1, "Medicine and Dentistry"=>7, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Social Sciences"=>1, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Social Sciences"=>{"Social Sciences"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Mathematics"=>{"Mathematics"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}}, "group_count"=>0}

Scopus | Further Information

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