Efficacy of antibiotherapy for treating flatus incontinence associated with small intestinal bacterial overgrowth: A pilot randomized trial
Publication Date
August 01, 2017
Authors
Chloé Melchior, Guillaume Gourcerol, Valérie Bridoux, Philippe Ducrotté, et al
Volume
12
Issue
8
Pages
e0180835
DOI
https://dx.plos.org/10.1371/journal.pone.0180835
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0180835
Scopus
85026540729
Mendeley
http://www.mendeley.com/research/efficacy-antibiotherapy-treating-flatus-incontinence-associated-small-intestinal-bacterial-overgrowt
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Mendeley | Further Information

{"title"=>"Efficacy of antibiotherapy for treating flatus incontinence associated with small intestinal bacterial overgrowth: A pilot randomized trial", "type"=>"journal", "authors"=>[{"first_name"=>"Chloé", "last_name"=>"Melchior", "scopus_author_id"=>"55241501900"}, {"first_name"=>"Guillaume", "last_name"=>"Gourcerol", "scopus_author_id"=>"6506887187"}, {"first_name"=>"Valérie", "last_name"=>"Bridoux", "scopus_author_id"=>"23017807000"}, {"first_name"=>"Philippe", "last_name"=>"Ducrotté", "scopus_author_id"=>"7006732860"}, {"first_name"=>"Jean François", "last_name"=>"Quinton", "scopus_author_id"=>"7003519674"}, {"first_name"=>"Anne Marie", "last_name"=>"Leroi", "scopus_author_id"=>"16555385000"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1111111111", "pmid"=>"28763464", "scopus"=>"2-s2.0-85026540729", "pui"=>"617593697", "doi"=>"10.1371/journal.pone.0180835", "sgr"=>"85026540729"}, "id"=>"0f16e6fa-2863-37dd-b1b7-7623f32bef24", "abstract"=>"AIM An increase in intestinal gas production due to small intestinal bowel overgrowth (SIBO) is a contributing factor for flatus incontinence. The aims of our study were to assess the efficacy of metronidazole in a select population of patients with flatus incontinence associated with SIBO and to compare its efficacy with that of a combination of simethicone and activated charcoal (SC; Carbosylane) in randomized experimental arms. METHODS Adult patients suffering from flatus incontinence associated with SIBO diagnosed by a glucose breath test were enrolled in the study. They were given metronidazole or Carbosylane (SC) for 10 days. The reduction in the mean daily number of gas leakages reported in a 3-day diary before and at the end of the treatment was used as the primary endpoint. RESULTS Of 52 consecutive subjects with flatus incontinence, 23 (44%) had SIBO, 16 (33%) of whom were included in and completed the study. The relative reduction in flatus incontinence episodes was significantly higher in the metronidazole than in the SC group (66.8±34.8% vs. 25±50%, P = 0.03), decreasing by more than 50% in 7 (87.5%) of the subjects in the metronidazole group compared with only 1 (12.5%) in the SC group (odds ratio 1.9, 95% confidence interval 0.9-56.9, P = 0.06). CONCLUSION Our results show a promising trend indicating that metronidazole might significantly improve flatus incontinence associated with SIBO and might be more successful in treating flatus incontinence than gas absorbents.", "link"=>"http://www.mendeley.com/research/efficacy-antibiotherapy-treating-flatus-incontinence-associated-small-intestinal-bacterial-overgrowt", "reader_count"=>6, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>1, "Student > Bachelor"=>1, "Student > Master"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>1, "Student > Bachelor"=>1, "Student > Master"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Medicine and Dentistry"=>2, "Nursing and Health Professions"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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