Longitudinal increases of brain metabolite levels in 5-10 year old children
Publication Date
July 11, 2017
Authors
Martha J. Holmes, Frances C. Robertson, Francesca Little, Steven R. Randall, et al
Volume
12
Issue
7
Pages
e0180973
DOI
https://dx.plos.org/10.1371/journal.pone.0180973
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0180973
Scopus
85023203019
Mendeley
http://www.mendeley.com/research/longitudinal-increases-brain-metabolite-levels-510-year-old-children
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Mendeley | Further Information

{"title"=>"Longitudinal increases of brain metabolite levels in 5-10 year old children", "type"=>"journal", "authors"=>[{"first_name"=>"Martha J.", "last_name"=>"Holmes", "scopus_author_id"=>"57158571800"}, {"first_name"=>"Frances C.", "last_name"=>"Robertson", "scopus_author_id"=>"50462362800"}, {"first_name"=>"Francesca", "last_name"=>"Little", "scopus_author_id"=>"7005195310"}, {"first_name"=>"Steven R.", "last_name"=>"Randall", "scopus_author_id"=>"57194834044"}, {"first_name"=>"Mark F.", "last_name"=>"Cotton", "scopus_author_id"=>"36949038700"}, {"first_name"=>"Andre J.W.", "last_name"=>"Van Der Kouwe", "scopus_author_id"=>"6603366943"}, {"first_name"=>"Barbara", "last_name"=>"Laughton", "scopus_author_id"=>"36101192500"}, {"first_name"=>"Ernesta M.", "last_name"=>"Meintjes", "scopus_author_id"=>"6603504548"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85023203019", "sgr"=>"85023203019", "doi"=>"10.1371/journal.pone.0180973", "isbn"=>"1111111111", "issn"=>"19326203", "pui"=>"617260811"}, "id"=>"d912eddc-f064-3539-b995-13bcfbda8107", "abstract"=>"© 2017 Holmes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the originalauthor and source are credited. Longitudinal magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) studies reveal significant changes in brain structure and structural networks that occur together with cognitive and behavioral maturation in childhood. However, the underlying cellular changes accompanying brain maturation are less understood. Examining regional agerelated changes in metabolite levels provides insight into the physiology of neurodevelopment. Magnetic resonance spectroscopy (MRS) measures localize brain metabolism. The majority of neuroimaging studies of healthy development are from the developed world. In a longitudinal MRS study of 64 South African children aged 5 to 10 years old (29 female; 29 HIV exposed, uninfected), we examined the age-related trajectories of creatine (Cr +PCr), N-acetyl-aspartate (NAA), the combined NAA+N-acetyl-aspartyl-glutamate (NAAG), choline (GPC+PCh), glutamate (Glu) and the combined Glu+glutamine (Glu +Gln) in voxels within gray and white matter, as well as subcortically in the basal ganglia (BG). In frontal gray matter, we found age-related increases in Cr+PCr, NAA, NAA+NAAG and Glu+Gln levels pointing to synaptic activity likely related to learning. In the BG we observed increased levels of Glu, Glu+Gln and NAA+NAAG with age that point to subcortical synaptic reorganization. In white matter, we found increased levels of Cr+PCr, NAA, NAA+NAAG, Glu and Glu+Gln with age, implicating these metabolites in ongoing myelination. We observed no sex-age or HIV exposure-age interactions, indicating that physiological changes are independent of sex during this time period. The metabolite trajectories presented, therefore, provide a critical benchmark of normal cellular growth for a low socioeconomic pediatric population in the developing world against which pathology and abnormal development may be compared.", "link"=>"http://www.mendeley.com/research/longitudinal-increases-brain-metabolite-levels-510-year-old-children", "reader_count"=>13, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>3, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>3, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>1, "Sports and Recreations"=>1, "Physics and Astronomy"=>1, "Computer Science"=>1, "Psychology"=>1, "Engineering"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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