A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial
Publication Date
July 18, 2017
Authors
Kirsten E. Bell, Tim Snijders, Michael Zulyniak, Dinesh Kumbhare, et al
Volume
12
Issue
7
Pages
e0181387
DOI
https://dx.plos.org/10.1371/journal.pone.0181387
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0181387
Scopus
85025087563
Mendeley
http://www.mendeley.com/research/whey-proteinbased-multiingredient-nutritional-supplement-stimulates-gains-lean-body-mass-strength-he
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Mendeley | Further Information

{"title"=>"A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial", "type"=>"journal", "authors"=>[{"first_name"=>"Kirsten E.", "last_name"=>"Bell", "scopus_author_id"=>"55414355200"}, {"first_name"=>"Tim", "last_name"=>"Snijders", "scopus_author_id"=>"35094565000"}, {"first_name"=>"Michael", "last_name"=>"Zulyniak", "scopus_author_id"=>"57200970979"}, {"first_name"=>"Dinesh", "last_name"=>"Kumbhare", "scopus_author_id"=>"6507305163"}, {"first_name"=>"Gianni", "last_name"=>"Parise", "scopus_author_id"=>"7007155823"}, {"first_name"=>"Adrian", "last_name"=>"Chabowski", "scopus_author_id"=>"6602796252"}, {"first_name"=>"Stuart M.", "last_name"=>"Phillips", "scopus_author_id"=>"7402028911"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1111111111", "pmid"=>"28719669", "scopus"=>"2-s2.0-85025087563", "pui"=>"617351810", "doi"=>"10.1371/journal.pone.0181387", "sgr"=>"85025087563"}, "id"=>"8e5430f3-c8e7-34f6-baef-baa6676ddf8d", "abstract"=>"Protein and other compounds can exert anabolic effects on skeletal muscle, particularly in conjunction with exercise. The objective of this study was to evaluate the efficacy of twice daily consumption of a protein-based, multi-ingredient nutritional supplement to increase strength and lean mass independent of, and in combination with, exercise in healthy older men. Forty-nine healthy older men (age: 73 ± 1 years [mean ± SEM]; BMI: 28.5 ± 1.5 kg/m2) were randomly allocated to 20 weeks of twice daily consumption of either a nutritional supplement (SUPP; n = 25; 30 g whey protein, 2.5 g creatine, 500 IU vitamin D, 400 mg calcium, and 1500 mg n-3 PUFA with 700 mg as eicosapentanoic acid and 445 mg as docosahexanoic acid); or a control (n = 24; CON; 22 g of maltodextrin). The study had two phases. Phase 1 was 6 weeks of SUPP or CON alone. Phase 2 was a 12 week continuation of the SUPP/CON but in combination with exercise: SUPP + EX or CON + EX. Isotonic strength (one repetition maximum [1RM]) and lean body mass (LBM) were the primary outcomes. In Phase 1 only the SUPP group gained strength (Σ1RM, SUPP: +14 ± 4 kg, CON: +3 ± 2 kg, P < 0.001) and lean mass (LBM, +1.2 ± 0.3 kg, CON: -0.1 ± 0.2 kg, P < 0.001). Although both groups gained strength during Phase 2, upon completion of the study upper body strength was greater in the SUPP group compared to the CON group (Σ upper body 1RM: 119 ± 4 vs. 109 ± 5 kg, P = 0.039). We conclude that twice daily consumption of a multi-ingredient nutritional supplement increased muscle strength and lean mass in older men. Increases in strength were enhanced further with exercise training. TRIAL REGISTRATION ClinicalTrials.gov NCT02281331.", "link"=>"http://www.mendeley.com/research/whey-proteinbased-multiingredient-nutritional-supplement-stimulates-gains-lean-body-mass-strength-he", "reader_count"=>67, "reader_count_by_academic_status"=>{"Unspecified"=>10, "Researcher"=>11, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Student > Master"=>10, "Other"=>7, "Student > Bachelor"=>10, "Lecturer"=>1, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>10, "Researcher"=>11, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Student > Master"=>10, "Other"=>7, "Student > Bachelor"=>10, "Lecturer"=>1, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>12, "Engineering"=>1, "Nursing and Health Professions"=>9, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>15, "Medicine and Dentistry"=>12, "Sports and Recreations"=>9, "Chemistry"=>1, "Social Sciences"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>9}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>9}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>12}}, "group_count"=>8}

Scopus | Further Information

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