Intestinal Ralstonia pickettii augments glucose intolerance in obesity
Publication Date
November 22, 2017
Authors
Shanthadevi D. Udayappan, Petia Kovatcheva Datchary, Guido J. Bakker, Stefan R. Havik, et al
Volume
12
Issue
11
Pages
e0181693
DOI
https://dx.plos.org/10.1371/journal.pone.0181693
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0181693
Scopus
85034833566
Mendeley
http://www.mendeley.com/research/intestinal-ralstonia-pickettii-augments-glucose-intolerance-obesity
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Mendeley | Further Information

{"title"=>"Intestinal Ralstonia pickettii augments glucose intolerance in obesity", "type"=>"journal", "authors"=>[{"first_name"=>"Shanthadevi D.", "last_name"=>"Udayappan", "scopus_author_id"=>"56269618200"}, {"first_name"=>"Petia", "last_name"=>"Kovatcheva-Datchary", "scopus_author_id"=>"26429789500"}, {"first_name"=>"Guido J.", "last_name"=>"Bakker", "scopus_author_id"=>"56902402800"}, {"first_name"=>"Stefan R.", "last_name"=>"Havik", "scopus_author_id"=>"9237581100"}, {"first_name"=>"Hilde", "last_name"=>"Herrema", "scopus_author_id"=>"24447878100"}, {"first_name"=>"Patrice D.", "last_name"=>"Cani", "scopus_author_id"=>"6507917827"}, {"first_name"=>"Kristien E.", "last_name"=>"Bouter", "scopus_author_id"=>"55909899400"}, {"first_name"=>"Clara", "last_name"=>"Belzer", "scopus_author_id"=>"24390612500"}, {"first_name"=>"Julia J.", "last_name"=>"Witjes", "scopus_author_id"=>"56462316200"}, {"first_name"=>"Anne", "last_name"=>"Vrieze", "scopus_author_id"=>"55340004300"}, {"first_name"=>"Noor", "last_name"=>"De Sonnaville", "scopus_author_id"=>"57197799286"}, {"first_name"=>"Alice", "last_name"=>"Chaplin", "scopus_author_id"=>"56606906000"}, {"first_name"=>"Daniel H.", "last_name"=>"Van Raalte", "scopus_author_id"=>"8982128200"}, {"first_name"=>"Steven", "last_name"=>"Aalvink", "scopus_author_id"=>"57192109944"}, {"first_name"=>"Geesje M.", "last_name"=>"Dallinga-Thie", "scopus_author_id"=>"35473880200"}, {"first_name"=>"Hans G.H.J.", "last_name"=>"Heilig", "scopus_author_id"=>"6603576727"}, {"first_name"=>"Göran", "last_name"=>"Bergström", "scopus_author_id"=>"16041740100"}, {"first_name"=>"Suzan", "last_name"=>"Van Der Meij", "scopus_author_id"=>"15726452800"}, {"first_name"=>"Bart A.", "last_name"=>"Van Wagensveld", "scopus_author_id"=>"6603231890"}, {"first_name"=>"Joost B.L.", "last_name"=>"Hoekstra", "scopus_author_id"=>"7102701496"}, {"first_name"=>"Frits", "last_name"=>"Holleman", "scopus_author_id"=>"6602805434"}, {"first_name"=>"Erik S.G.", "last_name"=>"Stroes", "scopus_author_id"=>"7004092642"}, {"first_name"=>"Albert K.", "last_name"=>"Groen", "scopus_author_id"=>"35242574800"}, {"first_name"=>"Fredrik", "last_name"=>"Bäckhed", "scopus_author_id"=>"57193396141"}, {"first_name"=>"Willem M.", "last_name"=>"De Vos", "scopus_author_id"=>"35495729400"}, {"first_name"=>"Max", "last_name"=>"Nieuwdorp", "scopus_author_id"=>"22433607700"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1111111111", "pmid"=>"29166392", "scopus"=>"2-s2.0-85034833566", "pui"=>"619359947", "doi"=>"10.1371/journal.pone.0181693", "sgr"=>"85034833566"}, "id"=>"6fddc21a-1a87-3180-8a5a-87e36966dfc4", "abstract"=>"An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. Here, we report that bacterial DNA is present in mesenteric adipose tissue of obese but otherwise healthy human subjects. Pyrosequencing of bacterial 16S rRNA genes revealed that DNA from the Gram-negative species Ralstonia was most prevalent. Interestingly, fecal abundance of Ralstonia pickettii was increased in obese subjects with pre-diabetes and T2DM. To assess if R. pickettii was causally involved in development of obesity and T2DM, we performed a proof-of-concept study in diet-induced obese (DIO) mice. Compared to vehicle-treated control mice, R. pickettii-treated DIO mice had reduced glucose tolerance. In addition, circulating levels of endotoxin were increased in R. pickettii-treated mice. In conclusion, this study suggests that intestinal Ralstonia is increased in obese human subjects with T2DM and reciprocally worsens glucose tolerance in DIO mice.", "link"=>"http://www.mendeley.com/research/intestinal-ralstonia-pickettii-augments-glucose-intolerance-obesity", "reader_count"=>28, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>4, "Nursing and Health Professions"=>2, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>5, "Psychology"=>1, "Immunology and Microbiology"=>1, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>5}}, "group_count"=>1}

Scopus | Further Information

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