Conformational risk factors of brachycephalic obstructive airway syndrome (BOAS) in pugs, French bulldogs, and bulldogs
Publication Date
August 01, 2017
Authors
Nai Chieh Liu, Eileen L. Troconis, Lajos Kalmar, David J. Price, et al
Volume
12
Issue
8
Pages
e0181928
DOI
https://dx.plos.org/10.1371/journal.pone.0181928
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0181928
Scopus
85026552709
Mendeley
http://www.mendeley.com/research/conformational-risk-factors-brachycephalic-obstructive-airway-syndrome-boas-pugs-french-bulldogs-bul
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Mendeley | Further Information

{"title"=>"Conformational risk factors of brachycephalic obstructive airway syndrome (BOAS) in pugs, French bulldogs, and bulldogs", "type"=>"journal", "authors"=>[{"first_name"=>"Nai Chieh", "last_name"=>"Liu", "scopus_author_id"=>"56735069100"}, {"first_name"=>"Eileen L.", "last_name"=>"Troconis", "scopus_author_id"=>"57195252087"}, {"first_name"=>"Lajos", "last_name"=>"Kalmar", "scopus_author_id"=>"57189236658"}, {"first_name"=>"David J.", "last_name"=>"Price", "scopus_author_id"=>"57072410100"}, {"first_name"=>"Hattie E.", "last_name"=>"Wright", "scopus_author_id"=>"57195248969"}, {"first_name"=>"Vicki J.", "last_name"=>"Adams", "scopus_author_id"=>"7102033262"}, {"first_name"=>"David R.", "last_name"=>"Sargan", "scopus_author_id"=>"7004105709"}, {"first_name"=>"Jane F.", "last_name"=>"Ladlow", "scopus_author_id"=>"6602304923"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85026552709", "pmid"=>"28763490", "pui"=>"617593749", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85026552709", "doi"=>"10.1371/journal.pone.0181928", "issn"=>"19326203"}, "id"=>"cdc72b19-a3c4-36cd-bb12-0cfec5807f79", "abstract"=>"Extremely brachycephalic, or short-muzzled, dog breeds such as pugs, French bulldogs, and bulldogs are prone to the conformation-related respiratory disorder-brachycephalic obstructive airway syndrome (BOAS). Affected dogs present with a wide range of clinical signs from snoring and exercise intolerance, to life-threatening events such as syncope. In this study, conformational risk factors for BOAS that could potentially aid in breeding away from BOAS were sought. Six hundred and four pugs, French bulldogs, and bulldogs were included in the study. Soft tape measurements of the head and body were used and the inter-observer reproducibility was evaluated. Breed-specific models were developed to assess the associations between the conformational factors and BOAS status based on functional grading. The models were further validated by means of a BOAS index, which is an objective measurement of respiratory function using whole-body barometric plethysmography. The final models have good predictive power for discriminating BOAS (-) and BOAS (+) phenotypes indicated by the area under the curve values of >80% on the receiver operating curves. When other factors were controlled, stenotic nostrils were associated with BOAS in all three breeds; pugs and bulldogs with higher body condition scores (BCS) had a higher risk of developing BOAS. Among the standardized conformational measurements (i.e. craniofacial ratio (CFR), eye width ratio (EWR), skull index (SI), neck girth ratio (NGR), and neck length ratio (NLR)), for pugs EWR and SI, for French bulldogs NGR and NLR, and for bulldogs SI and NGR showed significant associations with BOAS status. However, the NGR in bulldogs was the only significant predictor that also had satisfactory inter-observer reproducibility. A NGR higher than 0.71 in male bulldogs was predictive of BOAS with approximately 70% sensitivity and specificity. In conclusion, stenotic nostrils, BCS, and NGR were found to be valid, easily applicable predictors for BOAS (+).", "link"=>"http://www.mendeley.com/research/conformational-risk-factors-brachycephalic-obstructive-airway-syndrome-boas-pugs-french-bulldogs-bul", "reader_count"=>26, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Researcher"=>4, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>3, "Other"=>2, "Student > Master"=>3, "Student > Bachelor"=>8, "Student > Doctoral Student"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Researcher"=>4, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>3, "Other"=>2, "Student > Master"=>3, "Student > Bachelor"=>8, "Student > Doctoral Student"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>2, "Mathematics"=>1, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>2, "Veterinary Science and Veterinary Medicine"=>10, "Psychology"=>1, "Sports and Recreations"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Psychology"=>{"Psychology"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>10}}, "group_count"=>1}

Scopus | Further Information

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