Mendeley | Further Information

{"title"=>"18F-FDG-PET/CT for the detection of disease in patients with head and neck cancer treated with radiotherapy", "type"=>"journal", "authors"=>[{"first_name"=>"Nils", "last_name"=>"Helsen", "scopus_author_id"=>"57195274829"}, {"first_name"=>"Dessie", "last_name"=>"Roothans", "scopus_author_id"=>"55595720000"}, {"first_name"=>"Bert", "last_name"=>"Van Den Heuvel", "scopus_author_id"=>"57195274698"}, {"first_name"=>"Tim", "last_name"=>"Van Den Wyngaert", "scopus_author_id"=>"14319443800"}, {"first_name"=>"Danielle", "last_name"=>"Van Den Weyngaert", "scopus_author_id"=>"6602929657"}, {"first_name"=>"Laurens", "last_name"=>"Carp", "scopus_author_id"=>"9234868500"}, {"first_name"=>"Sigrid", "last_name"=>"Stroobants", "scopus_author_id"=>"7003717481"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85026745524", "doi"=>"10.1371/journal.pone.0182350", "pui"=>"617642151", "pmid"=>"28771540", "scopus"=>"2-s2.0-85026745524", "issn"=>"19326203"}, "id"=>"3439b4d2-b342-3d2e-a473-514419d3f985", "abstract"=>"OBJECTIVE The aim of this study is to evaluate the diagnostic performance of FDG-PET/CT for the detection of residual disease after (chemo)radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) and to evaluate the prognostic value of the FDG-PET/CT findings. METHODS Patients with HNSCC who underwent FDG-PET/CT after (chemo)radiotherapy were studied retrospectively. RESULTS 104 FDG-PET/CT-scans were performed at a median of 13.2 weeks post-treatment (5.4-19.0 weeks). The diagnostic performance was time dependent with decreasing sensitivity and slightly increasing specificity over time. Sensitivity, specificity, PPV and NPV at 9 months after imaging were 91%, 87%, 77% and 95%, respectively. In a logistic regression model, the odds of a correct FDG-PET/CT increased with 33% every additional week after end of therapy (p = 0.01) and accuracy plateaued after 11 weeks (97%; p<0.001). A complete response on FDG-PET/CT was associated with an overall survival benefit (50.7 versus 10.3 months; p<0.001). Residual disease on FDG-PET/CT increased the risk of death 8-fold (p<0.001). CONCLUSION FDG-PET/CT is able to detect residual disease after (chemo)radiotherapy, with an optimal time point for scanning between 11-12 weeks after therapy. However, a reevaluation is probably necessary 10-12 months after the FDG-PET/CT to detect late recurrences. In addition, FDG-PET/CT can guide decisions about neck dissection and identifies patients with poor prognosis.", "link"=>"http://www.mendeley.com/research/18ffdgpetct-detection-disease-patients-head-neck-cancer-treated-radiotherapy-1", "reader_count"=>3, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Other"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Other"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}}, "group_count"=>0}

CrossRef

• http://doi.org/10.1007/s40134-018-0262-z
• http://doi.org/10.1007/s00259-020-04710-4
• http://doi.org/10.1016/j.clon.2018.11.036
• http://doi.org/10.1093/carcin/bgz075
• http://doi.org/10.1055/a-1218-5129
• http://doi.org/10.1016/j.radonc.2020.08.004
• http://doi.org/10.3389/fonc.2020.01458
• http://doi.org/10.1017/S0022215120000651
• http://doi.org/10.1007/s00259-018-3978-3

Scopus | Further Information

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