Identification of novel biomarkers to monitor β-cell function and enable early detection of type 2 diabetes risk
Publication Date
August 28, 2017
Authors
Kirstine J. Belongie, Ele Ferrannini, Kjell Johnson, Patricia Andrade Gordon, et al
Volume
12
Issue
8
Pages
e0182932
DOI
https://dx.plos.org/10.1371/journal.pone.0182932
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0182932
Scopus
85028532405
Mendeley
http://www.mendeley.com/research/identification-novel-biomarkers-monitor-%CE%B2cell-function-enable-early-detection-type-2-diabetes-risk
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Mendeley | Further Information

{"title"=>"Identification of novel biomarkers to monitor β-cell function and enable early detection of type 2 diabetes risk", "type"=>"journal", "authors"=>[{"first_name"=>"Kirstine J.", "last_name"=>"Belongie", "scopus_author_id"=>"57195517042"}, {"first_name"=>"Ele", "last_name"=>"Ferrannini", "scopus_author_id"=>"34975069200"}, {"first_name"=>"Kjell", "last_name"=>"Johnson", "scopus_author_id"=>"46661090800"}, {"first_name"=>"Patricia", "last_name"=>"Andrade-Gordon", "scopus_author_id"=>"7005401610"}, {"first_name"=>"Michael K.", "last_name"=>"Hansen", "scopus_author_id"=>"57192994352"}, {"first_name"=>"John R.", "last_name"=>"Petrie", "scopus_author_id"=>"7103382892"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"618032376", "sgr"=>"85028532405", "scopus"=>"2-s2.0-85028532405", "pmid"=>"28846711", "doi"=>"10.1371/journal.pone.0182932", "isbn"=>"1111111111"}, "id"=>"1761f1d0-3aa9-3cac-b1a7-985ee0185c41", "abstract"=>"A decline in β-cell function is a prerequisite for the development of type 2 diabetes, yet the level of β-cell function in individuals at risk of the condition is rarely measured. This is due, in part, to the fact that current methods for assessing β-cell function are inaccurate, prone to error, labor-intensive, or affected by glucose-lowering therapy. The aim of the current study was to identify novel circulating biomarkers to monitor β-cell function and to identify individuals at high risk of developing β-cell dysfunction. In a nested case-control study from the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort (n = 1157), proteomics and miRNA profiling were performed on fasting plasma samples from 43 individuals who progressed to impaired glucose tolerance (IGT) and 43 controls who maintained normal glucose tolerance (NGT) over three years. Groups were matched at baseline for age, gender, body mass index (BMI), insulin sensitivity (euglycemic clamp) and β-cell glucose sensitivity (mathematical modeling). Proteomic profiling was performed using the SomaLogic platform (Colorado, USA); miRNA expression was performed using a modified RT-PCR protocol (Regulus Therapeutics, California, USA). Results showed differentially expressed proteins and miRNAs including some with known links to type 2 diabetes, such as adiponectin, but also novel biomarkers and pathways. In cross sectional analysis at year 3, the top differentially expressed biomarkers in people with IGT/ reduced β-cell glucose sensitivity were adiponectin, alpha1-antitrypsin (known to regulate adiponectin levels), endocan, miR-181a, miR-342, and miR-323. At baseline, adiponectin, cathepsin D and NCAM.L1 (proteins expressed by pancreatic β-cells) were significantly lower in those that progressed to IGT. Many of the novel prognostic biomarker candidates were within the epithelial-mesenchymal transition (EMT) pathway: for example, Noggin, DLL4 and miR-181a. Further validation studies are required in additional clinical cohorts and in patients with type 2 diabetes, but these results identify novel pathways and biomarkers that may have utility in monitoring β-cell function and/ or predicting future decline, allowing more targeted efforts to prevent and intercept type 2 diabetes.", "link"=>"http://www.mendeley.com/research/identification-novel-biomarkers-monitor-%CE%B2cell-function-enable-early-detection-type-2-diabetes-risk", "reader_count"=>15, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>1, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>1, "Chemistry"=>1, "Psychology"=>1, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>0}

Scopus | Further Information

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