Alternative vaccine administration by powder injection: Needle-free dermal delivery of the glycoconjugate meningococcal group Y vaccine
Publication Date
August 24, 2017
Authors
Nikolas T. Weissmueller, Leanne Marsay, Heiko A. Schiffter, Robert C. Carlisle, et al
Volume
12
Issue
8
Pages
e0183427
DOI
https://dx.plos.org/10.1371/journal.pone.0183427
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0183427
Scopus
85028419941
Mendeley
http://www.mendeley.com/research/alternative-vaccine-administration-powder-injection-needlefree-dermal-delivery-glycoconjugate-mening
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Mendeley | Further Information

{"title"=>"Alternative vaccine administration by powder injection: Needle-free dermal delivery of the glycoconjugate meningococcal group Y vaccine", "type"=>"journal", "authors"=>[{"first_name"=>"Nikolas T.", "last_name"=>"Weissmueller", "scopus_author_id"=>"55765651100"}, {"first_name"=>"Leanne", "last_name"=>"Marsay", "scopus_author_id"=>"55747779300"}, {"first_name"=>"Heiko A.", "last_name"=>"Schiffter", "scopus_author_id"=>"12344937600"}, {"first_name"=>"Robert C.", "last_name"=>"Carlisle", "scopus_author_id"=>"7006960540"}, {"first_name"=>"Christine S.", "last_name"=>"Rollier", "scopus_author_id"=>"6602327652"}, {"first_name"=>"Robert K.", "last_name"=>"Prud’Homme", "scopus_author_id"=>"7103032904"}, {"first_name"=>"Andrew J.", "last_name"=>"Pollard", "scopus_author_id"=>"7103193821"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"617960556", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0183427", "scopus"=>"2-s2.0-85028419941", "pmid"=>"28837693", "sgr"=>"85028419941"}, "id"=>"338fdf82-8ad3-3791-bbde-117880165557", "abstract"=>"Powder-injectors use gas propulsion to deposit lyophilised drug or vaccine particles in the epidermal and sub epidermal layers of the skin. We prepared dry-powder (Tg = 45.2 +/- 0.5 degrees C) microparticles (58.1 mum) of a MenY-CRM197 glyconjugate vaccine (0.5% wt.) for intradermal needle-free powder injection (NFPI). SFD used ultrasound atomisation of the liquid vaccine-containing excipient feed, followed by lyophilisation above the glass transition temperature (Tg' = - 29.9 +/- 0.3 degrees C). This resulted in robust particles (density~ 0.53 +/-0.09 g/cm3) with a narrow volume size distribution (mean diameter 58.1 mum, and span = 1.2), and an impact parameter (rhovr ~ 11.5 kg/m.s) sufficient to breach the Stratum corneum (sc). The trehalose, manitol, dextran (10 kDa), dextran (150 kDa) formulation, or TMDD (3:3:3:1), protected the MenY-CRM197 glyconjugate during SFD with minimal loss, no detectable chemical degradation or physical aggregation. In a capsular group Y Neisseria meningitidis serum bactericidal assay (SBA) with human serum complement, the needle free vaccine, which contained no alum adjuvant, induced functional protective antibody responses in vivo of similar magnitude to the conventional vaccine injected by hypodermic needle and syringe and containing alum adjuvant. These results demonstrate that needle-free vaccination is both technically and immunologically valid, and could be considered for vaccines in development.", "link"=>"http://www.mendeley.com/research/alternative-vaccine-administration-powder-injection-needlefree-dermal-delivery-glycoconjugate-mening", "reader_count"=>8, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Veterinary Science and Veterinary Medicine"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>1}

Scopus | Further Information

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