Adult hippocampal neurogenesis poststroke: More new granule cells but aberrant morphology and impaired spatial memory
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{"title"=>"Adult hippocampal neurogenesis poststroke: More new granule cells but aberrant morphology and impaired spatial memory", "type"=>"journal", "authors"=>[{"first_name"=>"Florus", "last_name"=>"Woitke", "scopus_author_id"=>"57195672386"}, {"first_name"=>"Mihai", "last_name"=>"Ceanga", "scopus_author_id"=>"35955809500"}, {"first_name"=>"Max", "last_name"=>"Rudolph", "scopus_author_id"=>"57195685073"}, {"first_name"=>"Fanny", "last_name"=>"Niv", "scopus_author_id"=>"55260645400"}, {"first_name"=>"Otto W.", "last_name"=>"Witte", "scopus_author_id"=>"35592935100"}, {"first_name"=>"Christoph", "last_name"=>"Redecker", "scopus_author_id"=>"6603413801"}, {"first_name"=>"Albrecht", "last_name"=>"Kunze", "scopus_author_id"=>"22134710800"}, {"first_name"=>"Silke", "last_name"=>"Keiner", "scopus_author_id"=>"22134959500"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85029476126", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85029476126", "pui"=>"618273257", "pmid"=>"28910298", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0183463"}, "id"=>"654c9c44-3c12-36ce-9378-b3059f80bd39", "abstract"=>"Article Authors Metrics Comments Related Content Abstract Introduction Methods Results Discussion Conclusions Supporting information Acknowledgments References Reader Comments (0) Media Coverage (2) Figures Abstract Stroke significantly stimulates neurogenesis in the adult dentate gyrus, though the functional role of this postlesional response is mostly unclear. Recent findings suggest that newborn neurons generated in the context of stroke may fail to correctly integrate into pre-existing networks. We hypothesized that increased neurogenesis in the dentate gyrus following stroke is associated with aberrant neurogenesis and impairment of hippocampus-dependent memory. To address these questions we used the middle cerebral artery occlusion model (MCAO) in mice. Animals were housed either under standard conditions or with free access to running wheels. Newborn granule cells were labelled with the thymidine analoque EdU and retroviral vectors. To assess memory performance, we employed a modified version of the Morris water maze (MWM) allowing differentiation between hippocampus dependent and independent learning strategies. Newborn neurons were morphologically analyzed using confocal microscopy and Neurolucida system at 7 weeks. We found that neurogenesis was significantly increased following MCAO. Animals with MCAO needed more time to localize the platform and employed less hippocampus-dependent search strategies in MWM versus controls. Confocal studies revealed an aberrant cell morphology with basal dendrites and an ectopic location (e.g. hilus) of new granule cells born in the ischemic brain. Running increased the number of new neurons but also enhanced aberrant neurogenesis. Running, did not improve the general performance in the MWM but slightly promoted the application of precise spatial search strategies. In conclusion, ischemic insults cause hippocampal-dependent memory deficits which are associated with aberrant neurogenesis in the dentate gyrus indicating ischemia-induced maladaptive plasticity in the hippocampus", "link"=>"http://www.mendeley.com/research/adult-hippocampal-neurogenesis-poststroke-more-new-granule-cells-aberrant-morphology-impaired-spatia", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>3, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>3, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>2, "Neuroscience"=>6, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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