Differential diagnosis between Parkinson's disease and essential tremor using the smartphone's accelerometer
Publication Date
August 25, 2017
Authors
Sergi Barrantes, Antonio J. Sánchez Egea, Hernán A. González Rojas, Maria J. Martí, et al
Volume
12
Issue
8
Pages
e0183843
DOI
https://dx.plos.org/10.1371/journal.pone.0183843
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0183843
Scopus
85029177825
Mendeley
http://www.mendeley.com/research/differential-diagnosis-between-parkinsons-disease-essential-tremor-using-smartphones-accelerometer
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Mendeley | Further Information

{"title"=>"Differential diagnosis between Parkinson’s disease and essential tremor using the smartphone’s accelerometer", "type"=>"journal", "authors"=>[{"first_name"=>"Sergi", "last_name"=>"Barrantes", "scopus_author_id"=>"57195609497"}, {"first_name"=>"Antonio J.", "last_name"=>"Sánchez Egea", "scopus_author_id"=>"56025589300"}, {"first_name"=>"Hernán A.", "last_name"=>"González Rojas", "scopus_author_id"=>"23093833300"}, {"first_name"=>"Maria J.", "last_name"=>"Martí", "scopus_author_id"=>"35445809200"}, {"first_name"=>"Yaroslau", "last_name"=>"Compta", "scopus_author_id"=>"15080760700"}, {"first_name"=>"Francesc", "last_name"=>"Valldeoriola", "scopus_author_id"=>"35396953100"}, {"first_name"=>"Ester Simo", "last_name"=>"Mezquita", "scopus_author_id"=>"57195606939"}, {"first_name"=>"Eduard", "last_name"=>"Tolosa", "scopus_author_id"=>"35392145900"}, {"first_name"=>"Josep", "last_name"=>"Valls-Solè", "scopus_author_id"=>"55662030900"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85029177825", "sgr"=>"85029177825", "doi"=>"10.1371/journal.pone.0183843", "pui"=>"618215985", "pmid"=>"28841694", "isbn"=>"1111111111", "issn"=>"19326203"}, "id"=>"b2afeebf-d823-3364-b15a-8ffc4d7b02a8", "abstract"=>"BACKGROUND The differential diagnosis between patients with essential tremor (ET) and those with Parkinson's disease (PD) whose main manifestation is tremor may be difficult unless using complex neuroimaging techniques such as 123I-FP-CIT SPECT. We considered that using smartphone's accelerometer to stablish a diagnostic test based on time-frequency differences between PD an ET could support the clinical diagnosis. METHODS The study was carried out in 17 patients with PD, 16 patients with ET, 12 healthy volunteers and 7 patients with tremor of undecided diagnosis (TUD), who were re-evaluated one year after the first visit to reach the definite diagnosis. The smartphone was placed over the hand dorsum to record epochs of 30 s at rest and 30 s during arm stretching. We generated frequency power spectra and calculated receiver operating characteristics curves (ROC) curves of total spectral power, to establish a threshold to separate subjects with and without tremor. In patients with PD and ET, we found that the ROC curve of relative energy was the feature discriminating better between the two groups. This threshold was then used to classify the TUD patients. RESULTS We could correctly classify 49 out of 52 subjects in the category with/without tremor (97.96% sensitivity and 83.3% specificity) and 27 out of 32 patients in the category PD/ET (84.38% discrimination accuracy). Among TUD patients, 2 of 2 PD and 2 of 4 ET were correctly classified, and one patient having PD plus ET was classified as PD. CONCLUSIONS Based on the analysis of smartphone accelerometer recordings, we found several kinematic features in the analysis of tremor that distinguished first between healthy subjects and patients and, ultimately, between PD and ET patients. The proposed method can give immediate results for the clinician to gain valuable information for the diagnosis of tremor. This can be useful in environments where more sophisticated diagnostic techniques are unavailable.", "link"=>"http://www.mendeley.com/research/differential-diagnosis-between-parkinsons-disease-essential-tremor-using-smartphones-accelerometer", "reader_count"=>17, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>1, "Student > Postgraduate"=>1, "Professor > Associate Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>1, "Student > Postgraduate"=>1, "Professor > Associate Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Engineering"=>3, "Medicine and Dentistry"=>2, "Neuroscience"=>1, "Social Sciences"=>1, "Computer Science"=>4}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Computer Science"=>{"Computer Science"=>4}, "Unspecified"=>{"Unspecified"=>6}}, "group_count"=>1}

Scopus | Further Information

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