Mendeley | Further Information

{"title"=>"Validation of the 18-gene classifier as a prognostic biomarker of distant metastasis in breast cancer", "type"=>"journal", "authors"=>[{"first_name"=>"Skye Hung Chun", "last_name"=>"Cheng", "scopus_author_id"=>"56390265300"}, {"first_name"=>"Tzu Ting", "last_name"=>"Huang", "scopus_author_id"=>"57171216000"}, {"first_name"=>"Yu Hao", "last_name"=>"Cheng", "scopus_author_id"=>"57195632487"}, {"first_name"=>"Tee Benita Kiat", "last_name"=>"Tan", "scopus_author_id"=>"15832915800"}, {"first_name"=>"Chen Fang", "last_name"=>"Horng", "scopus_author_id"=>"57195628197"}, {"first_name"=>"Yong Alison", "last_name"=>"Wang", "scopus_author_id"=>"57189255299"}, {"first_name"=>"Nicholas Shannon", "last_name"=>"Brian", "scopus_author_id"=>"57195628129"}, {"first_name"=>"Li Sun", "last_name"=>"Shih", "scopus_author_id"=>"57117367200"}, {"first_name"=>"Ben Long", "last_name"=>"Yu", "scopus_author_id"=>"8433284100"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"618237742", "doi"=>"10.1371/journal.pone.0184372", "sgr"=>"85029374756", "scopus"=>"2-s2.0-85029374756", "isbn"=>"1111111111", "pmid"=>"28886126"}, "id"=>"6feda7f0-ef46-3de8-ae6a-a8016eaa9d2e", "abstract"=>"We validated an 18-gene classifier (GC) initially developed to predict local/regional recurrence after mastectomy in estimating distant metastasis risk. The 18-gene scoring algorithm defines scores as: <21, low risk; >/=21, high risk. Six hundred eighty-three patients with primary operable breast cancer and fresh frozen tumor tissues available were included. The primary outcome was the 5-year probability of freedom from distant metastasis (DMFP). Two external datasets were used to test the predictive accuracy of 18-GC. The 5-year rates of DMFP for patients classified as low-risk (n = 146, 21.7%) and high-risk (n = 537, 78.6%) were 96.2% (95% CI, 91.1%-98.8%) and 80.9% (74.6%-81.9%), respectively (median follow-up interval, 71.8 months). The 5-year rates of DMFP of the low-risk group in stage I (n = 62, 35.6%), stage II (n = 66, 20.1%), and stage III (n = 18, 10.3%) were 100%, 94.2% (78.5%-98.5%), and 90.9% (50.8%-98.7%), respectively. Multivariate analysis revealed that 18-GC is an independent prognostic factor of distant metastasis (adjusted hazard ratio, 5.1; 95% CI, 1.8-14.1; p = 0.0017) for scores of >/=21. External validation showed that the 5-year rate of DMFP in the low- and high-risk patients was 94.1% (82.9%-100%) and 80.3% (70.7%-89.9%, p = 0.06) in a Singapore dataset, and 89.5% (81.9%-94.1%) and 73.6% (67.2%-79.0%, p = 0.0039) in the GEO-GSE20685 dataset, respectively. In conclusion, 18-GC is a viable prognostic biomarker for breast cancer to estimate distant metastasis risk.", "link"=>"http://www.mendeley.com/research/validation-18gene-classifier-prognostic-biomarker-distant-metastasis-breast-cancer", "reader_count"=>3, "reader_count_by_academic_status"=>{"Student > Master"=>1, "Student > Ph. D. Student"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Student > Master"=>1, "Student > Ph. D. Student"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>2, "Biochemistry, Genetics and Molecular Biology"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>0}

CrossRef

• http://doi.org/10.1038/s41598-020-61535-9
• http://doi.org/10.1186/s41065-019-0096-6
• http://doi.org/10.1038/s41598-019-47046-2
• http://doi.org/10.1042/BSR20202794
• http://doi.org/10.3390/cancers12040913
• http://doi.org/10.1038/s43018-020-0106-7
• http://doi.org/10.1093/jjco/hyz102

Scopus | Further Information

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