Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology
Publication Date
September 21, 2017
Authors
Sarah E. Macdonald, Matthew J. Nolan, Kimberley Harman, Kay Boulton, et al
Volume
12
Issue
9
Pages
e0184890
DOI
https://dx.plos.org/10.1371/journal.pone.0184890
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0184890
Scopus
85029716100
Mendeley
http://www.mendeley.com/research/effects-eimeria-tenella-infection-chicken-caecal-microbiome-diversity-exploring-variation-associated
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology", "type"=>"journal", "authors"=>[{"first_name"=>"Sarah E.", "last_name"=>"Macdonald", "scopus_author_id"=>"57198073460"}, {"first_name"=>"Matthew J.", "last_name"=>"Nolan", "scopus_author_id"=>"7202696010"}, {"first_name"=>"Kimberley", "last_name"=>"Harman", "scopus_author_id"=>"57194975937"}, {"first_name"=>"Kay", "last_name"=>"Boulton", "scopus_author_id"=>"23033070600"}, {"first_name"=>"David A.", "last_name"=>"Hume", "scopus_author_id"=>"26032966400"}, {"first_name"=>"Fiona M.", "last_name"=>"Tomley", "scopus_author_id"=>"7004157035"}, {"first_name"=>"Richard A.", "last_name"=>"Stabler", "scopus_author_id"=>"7003483431"}, {"first_name"=>"Damer P.", "last_name"=>"Blake", "scopus_author_id"=>"7402494551"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0184890", "sgr"=>"85029716100", "isbn"=>"1111111111", "issn"=>"19326203", "scopus"=>"2-s2.0-85029716100", "pui"=>"618383610"}, "id"=>"daded2d1-8ce2-302b-8fe0-dbf4a16a893c", "abstract"=>"Eimeria species cause the intestinal disease coccidiosis, most notably in poultry. While the direct impact of coccidiosis on animal health and welfare is clear, its influence on the enteric microbiota and by-stander effects on chicken health and production remains largely unknown, with the possible exception of Clostridium perfringens (necrotic enteritis). This study evaluated the composition and structure of the caecal microbiome in the presence or absence of a defined Eimeria tenella challenge infection in Cobb500 broiler chickens using 16S rRNA amplicon sequencing. The severity of clinical coccidiosis in individual chickens was quantified by caecal lesion scoring and microbial changes associated with different lesion scores identified. Following E. tenella infection the diversity of taxa within the caecal microbiome remained largely stable. However, infection induced significant changes in the abundance of some microbial taxa. The greatest changes were detected in birds displaying severe caecal pathology; taxa belonging to the order Enterobacteriaceae were increased, while taxa from Bacillales and Lactobacillales were decreased with the changes correlated with lesion severity. Significantly different profiles were also detected in infected birds which remained asymptomatic (lesion score 0), with taxa belonging to the genera Bacteroides decreased and Lactobacillus increased. Many differential taxa from the order Clostridiales were identified, with some increasing and others decreasing in abundance in Eimeria-infected animals. The results support the view that caecal microbiome dysbiosis associated with Eimeria infection contributes to disease pathology, and could be a target for intervention to mitigate the impact of coccidiosis on poultry productivity and welfare. This work highlights that E. tenella infection has a significant impact on the abundance of some caecal bacteria with notable differences detected between lesion score categories emphasising the impor-tance of accounting for differences in caecal lesions when investigating the relationship between E. tenella and the poultry intestinal microbiome. Tomley FM, et al. (2017) Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology. PLoS ONE 12(9):", "link"=>"http://www.mendeley.com/research/effects-eimeria-tenella-infection-chicken-caecal-microbiome-diversity-exploring-variation-associated", "reader_count"=>13, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Professor"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Professor"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>5, "Veterinary Science and Veterinary Medicine"=>3, "Biochemistry, Genetics and Molecular Biology"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>3}}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85029716100"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85029716100?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029716100&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85029716100&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85029716100", "dc:identifier"=>"SCOPUS_ID:85029716100", "eid"=>"2-s2.0-85029716100", "dc:title"=>"Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology", "dc:creator"=>"Macdonald S.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"12", "prism:issueIdentifier"=>"9", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-09-01", "prism:coverDisplayDate"=>"September 2017", "prism:doi"=>"10.1371/journal.pone.0184890", "citedby-count"=>"9", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Royal Veterinary College University of London", "affiliation-city"=>"London", "affiliation-country"=>"United Kingdom"}], "pubmed-id"=>"28934262", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0184890", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Counter

  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"68", "xml_views"=>"8", "html_views"=>"153"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"70", "xml_views"=>"2", "html_views"=>"163"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"226"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"312"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"54", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"46", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"67", "xml_views"=>"2", "html_views"=>"46"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"37", "xml_views"=>"2", "html_views"=>"40"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"80", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"56", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"50", "xml_views"=>"4", "html_views"=>"40"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"73", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"52", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"77", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"64", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"65", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"83", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"95", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"72", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"35"}

PMC Usage Stats

  • {"unique-ip"=>"53", "full-text"=>"36", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"23", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"42", "full-text"=>"51", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"37", "full-text"=>"34", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"24", "full-text"=>"26", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"35", "full-text"=>"39", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"42", "full-text"=>"47", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"50", "full-text"=>"56", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"32", "full-text"=>"39", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"43", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"72", "full-text"=>"79", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"51", "full-text"=>"62", "pdf"=>"24", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"56", "full-text"=>"59", "pdf"=>"22", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"49", "full-text"=>"57", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"50", "full-text"=>"54", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"45", "full-text"=>"54", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"61", "full-text"=>"73", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"41", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"38", "full-text"=>"39", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"78", "full-text"=>"83", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"82", "full-text"=>"90", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"76", "full-text"=>"85", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
Loading … Spinner
There are currently no alerts