Osteopontin activates mesenchymal stem cells to repair skin wound
Publication Date
September 28, 2017
Authors
Wenping Wang, Pei Li, Wei Li, Junzi Jiang, et al
Volume
12
Issue
9
Pages
e0185346
DOI
https://dx.plos.org/10.1371/journal.pone.0185346
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0185346
Scopus
85030028613
Mendeley
http://www.mendeley.com/research/osteopontin-activates-mesenchymal-stem-cells-repair-skin-wound
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Mendeley | Further Information

{"title"=>"Osteopontin activates mesenchymal stem cells to repair skin wound", "type"=>"journal", "authors"=>[{"first_name"=>"Wenping", "last_name"=>"Wang", "scopus_author_id"=>"56367955800"}, {"first_name"=>"Pei", "last_name"=>"Li", "scopus_author_id"=>"57195914321"}, {"first_name"=>"Wei", "last_name"=>"Li", "scopus_author_id"=>"57196304053"}, {"first_name"=>"Junzi", "last_name"=>"Jiang", "scopus_author_id"=>"57195289262"}, {"first_name"=>"Yanyan", "last_name"=>"Cui", "scopus_author_id"=>"57195914720"}, {"first_name"=>"Shirong", "last_name"=>"Li", "scopus_author_id"=>"7409247542"}, {"first_name"=>"Zhenxiang", "last_name"=>"Wang", "scopus_author_id"=>"15057316100"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"618493110", "pmid"=>"28957406", "doi"=>"10.1371/journal.pone.0185346", "issn"=>"19326203", "scopus"=>"2-s2.0-85030028613", "sgr"=>"85030028613", "isbn"=>"1111111111"}, "id"=>"f6a87bda-028d-3907-aa66-0ec8bed5714d", "abstract"=>"Mesenchymal stem cells (MSCs) are promising candidates for skin wound repair due to their capabilities of accumulating at wounds and differentiating into multiple types of skin cells. However, the underlying mechanisms responsible for these processes remain unclear. In this study, we found that osteopontin (OPN) stimulated the migration of MSCs in vitro, and observed the recruitment of endogenous MSCs to a skin wound and their differentiation into keratinocytes and endothelial cells. In OPN knock-out mice, the recruitment of MSCs to the skin wound was significantly inhibited, and wound closure was hampered after an intradermal injection of exogenous MSCs compared to wild-type mice. Consistent with these observations, the expressions of adhesion molecule CD44 and its receptor E-selectin were significantly decreased in the lesions of OPN knock-out mice compared with wild-type mice suggesting that OPN may regulate the migration of MSCs through its interactions with CD44 during skin wound recovery. In summary, our data demonstrated that OPN played a critical role in activating the migration of MSCs to injured sites and their differentiation into specific skin cell types during skin wound healing.", "link"=>"http://www.mendeley.com/research/osteopontin-activates-mesenchymal-stem-cells-repair-skin-wound", "reader_count"=>8, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Other"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Other"=>2, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>3, "Chemical Engineering"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "group_count"=>0}

Scopus | Further Information

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