Nonalcoholic fatty liver disease is associated with an increased risk of heart block in hospitalized patients with type 2 diabetes mellitus
Publication Date
October 05, 2017
Authors
Alessandro Mantovani, Riccardo Rigolon, Isabella Pichiri, Stefano Bonapace, et al
Volume
12
Issue
10
Pages
e0185459
DOI
https://dx.plos.org/10.1371/journal.pone.0185459
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0185459
Scopus
85030723783
Mendeley
http://www.mendeley.com/research/nonalcoholic-fatty-liver-disease-associated-increased-risk-heart-block-hospitalized-patients-type-2
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Mendeley | Further Information

{"title"=>"Nonalcoholic fatty liver disease is associated with an increased risk of heart block in hospitalized patients with type 2 diabetes mellitus", "type"=>"journal", "authors"=>[{"first_name"=>"Alessandro", "last_name"=>"Mantovani", "scopus_author_id"=>"57200609626"}, {"first_name"=>"Riccardo", "last_name"=>"Rigolon", "scopus_author_id"=>"55757351700"}, {"first_name"=>"Isabella", "last_name"=>"Pichiri", "scopus_author_id"=>"25422183600"}, {"first_name"=>"Stefano", "last_name"=>"Bonapace", "scopus_author_id"=>"57195044526"}, {"first_name"=>"Giovanni", "last_name"=>"Morani", "scopus_author_id"=>"6506070786"}, {"first_name"=>"Giacomo", "last_name"=>"Zoppini", "scopus_author_id"=>"55398655800"}, {"first_name"=>"Enzo", "last_name"=>"Bonora", "scopus_author_id"=>"7004495052"}, {"first_name"=>"Giovanni", "last_name"=>"Targher", "scopus_author_id"=>"7003689424"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0185459", "sgr"=>"85030723783", "pui"=>"618616448", "scopus"=>"2-s2.0-85030723783", "issn"=>"19326203", "pmid"=>"28981521"}, "id"=>"7aea869a-9f82-3b12-80ac-5888d78113ad", "abstract"=>"Recent studies suggested that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiac tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus. The aim of this study was to examine whether an association also exists between NAFLD and heart block. We have retrospectively evaluated a hospital-based cohort of 751 patients with type 2 diabetes discharged from our Division of Diabetes and Endocrinology during years 2007-2014. Standard electrocardiograms were performed on all patients. Diagnosis of NAFLD was based on ultrasonography, whereas the severity of advanced hepatic fibrosis was based on the fibrosis (FIB)-4 score and other non-invasive fibrosis markers. Overall, 524 (69.8%) patients had NAFLD and 202 (26.9%) had heart block (defined as at least one block among first-degree atrio-ventricular block, second-degree block, third-degree block, left bundle branch block, right bundle branch block, left anterior hemi-block or left posterior hemi-block) on electrocardiograms. Patients with NAFLD had a remarkably higher prevalence of any persistent heart block than those without NAFLD (31.3% vs. 16.7%, p<0.001); this prevalence was particularly increased among those with higher FIB-4 score. NAFLD was associated with a threefold increased risk of prevalent heart block (adjusted-odds ratio 3.04, 95% CI 1.81-5.10), independently of age, sex, hypertension, prior ischemic heart disease, hemoglobin A1c, microvascular complication status, use of medications and other potentially confounding factors. In conclusion, this is the largest cross-sectional study to show that NAFLD and its severity are independently associated with an increased risk of prevalent heart block in hospitalized patients with type 2 diabetes.", "link"=>"http://www.mendeley.com/research/nonalcoholic-fatty-liver-disease-associated-increased-risk-heart-block-hospitalized-patients-type-2", "reader_count"=>3, "reader_count_by_academic_status"=>{"Student > Postgraduate"=>1, "Student > Master"=>2}, "reader_count_by_user_role"=>{"Student > Postgraduate"=>1, "Student > Master"=>2}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}}, "group_count"=>0}

Scopus | Further Information

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