MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1
Publication Date
October 10, 2017
Authors
Fei Yan Xie, Sumayyah Hosany, Shen Zhong, Yang Jiang, et al
Volume
12
Issue
10
Pages
e0185565
DOI
https://dx.plos.org/10.1371/journal.pone.0185565
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0185565
Scopus
85031025083
Mendeley
http://www.mendeley.com/research/microrna193a-inhibits-breast-cancer-proliferation-metastasis-downregulating-wt1-2
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Mendeley | Further Information

{"title"=>"MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1", "type"=>"journal", "authors"=>[{"first_name"=>"FeiYan", "last_name"=>"Xie"}, {"first_name"=>"Sumayyah", "last_name"=>"Hosany"}, {"first_name"=>"Shen", "last_name"=>"Zhong"}, {"first_name"=>"Yang", "last_name"=>"Jiang"}, {"first_name"=>"Fen", "last_name"=>"Zhang"}, {"first_name"=>"LiLi", "last_name"=>"Lin"}, {"first_name"=>"XiaoBo", "last_name"=>"Wang"}, {"first_name"=>"ShenMeng", "last_name"=>"Gao"}, {"first_name"=>"XiaoQu", "last_name"=>"Hu"}], "year"=>2017, "source"=>"PLOS ONE", "identifiers"=>{"isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0185565", "issn"=>"1932-6203", "pmid"=>"29016617"}, "id"=>"1d0eeb5c-9d27-3295-bee1-e6f2394c9111", "abstract"=>"In many cancers, microRNA-193a (miR-193a) is a suppressor miRNA, but its underlying anti-oncogenic activity in breast cancer is not known. In this study, we found decreased miR-193a (specifically, miR-193a-5p) expression not only in breast cancer cell lines but also in breast cancer tissues as compared with the adjacent non-tumor tissues. Ectopic miR-193a overexpression inhibited the proliferation, colony formation, migration, and invasion of MDA-MB-231 and BT549 cells. miR-193a reduced Wilms' tumor 1 (WT1) expression and repressed luciferase reporter activity by binding WT1 coding region sequences; mutation of the predicted miR-193a binding site abolished this effect. miR-193a and WT1 expression were significantly inversely correlated in breast cancer tissues. Importantly, the anti-cancer activity induced by miR-193a was partially reversed by WT1 overexpression, indicating an important role for WT1 in such activity related to miR-193a. Our results reveal that miR-193a-WT1 interaction plays an important role in breast cancer metastasis, and suggest that restoring miR-193a expression is a therapeutic strategy in breast cancer.", "link"=>"http://www.mendeley.com/research/microrna193a-inhibits-breast-cancer-proliferation-metastasis-downregulating-wt1-2", "reader_count"=>5, "reader_count_by_academic_status"=>{"Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Student > Postgraduate"=>2, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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