Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection
Publication Date
October 24, 2017
Authors
Swee Lin G. Chen Yi Mei, Alexander J. Thompson, Britt Christensen, Georgina Cunningham, et al
Volume
12
Issue
10
Pages
e0185609
DOI
https://dx.plos.org/10.1371/journal.pone.0185609
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0185609
Scopus
85032173835
Mendeley
http://www.mendeley.com/research/sustained-virological-response-halts-fibrosis-progression-longterm-followup-study-people-chronic-hep-3
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Mendeley | Further Information

{"title"=>"Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis C infection", "type"=>"journal", "authors"=>[{"first_name"=>"Swee Lin G.", "last_name"=>"Chen Yi Mei", "scopus_author_id"=>"37004322700"}, {"first_name"=>"Alexander J.", "last_name"=>"Thompson", "scopus_author_id"=>"56328011900"}, {"first_name"=>"Britt", "last_name"=>"Christensen", "scopus_author_id"=>"57196185392"}, {"first_name"=>"Georgina", "last_name"=>"Cunningham", "scopus_author_id"=>"56414250500"}, {"first_name"=>"Lucy", "last_name"=>"McDonald", "scopus_author_id"=>"57196194374"}, {"first_name"=>"Sally", "last_name"=>"Bell", "scopus_author_id"=>"7401587789"}, {"first_name"=>"David", "last_name"=>"Iser", "scopus_author_id"=>"16744265400"}, {"first_name"=>"Tin", "last_name"=>"Nguyen", "scopus_author_id"=>"24597920400"}, {"first_name"=>"Paul V.", "last_name"=>"Desmond", "scopus_author_id"=>"57196316048"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-85032173835", "pui"=>"618924979", "doi"=>"10.1371/journal.pone.0185609", "isbn"=>"1111111111", "sgr"=>"85032173835", "pmid"=>"29065124"}, "id"=>"9771b0a8-2104-30f4-8e5f-a4ea3d09ed51", "abstract"=>"BACKGROUND/AIMS Long-term follow-up studies validating the clinical benefit of sustained virological response (SVR) in people with chronic hepatitis C (CHC) infection are lacking. Our aim was to identify rates and predictors of liver fibrosis progression in a large, well characterized cohort of CHC patients in whom paired liver fibrosis assessments were performed more than 10 years apart. METHODS CHC patients who had undergone a baseline liver biopsy pre-2004 and a follow up liver fibrosis assessment more than 10 years later (biopsy or liver stiffness measurement (LSM) using transient elastography [FibroScan]) were identified. Subjects who had undergone a baseline liver biopsy but had no follow up fibrosis assessment were recalled for LSM. Fibrosis was categorised as mild-moderate (METAVIR F0-2 / LSM result of ≤ 9.5 kPa) or advanced (METAVIR F3-4/ LSM >9.5 kPa). The primary objective was to assess the association between SVR and the rate of liver fibrosis progression over at least 10 years, defined as an increase from mild-moderate fibrosis at baseline liver biopsy (METAVIR F0-2) to advanced fibrosis at follow-up liver fibrosis assessment. RESULTS 131 subjects were included in this analysis: 69% male, 82% Caucasian, 60% G1 HCV, 25% G3 HCV. The median age at F/U fibrosis staging was 57 (IQR 54-62) years with median estimated duration of infection 33-years (IQR 29-38). At F/U, liver fibrosis assessment was performed by LSM in 86% and liver biopsy in 14%. The median period between fibrosis assessments was 14-years (IQR 12-17). 109 (83%) participants had received interferon-based antiviral therapy. 40% attained SVR. At F/U, there was a significant increase in the proportion of subjects with advanced liver fibrosis: 27% at baseline vs. 46% at F/U (p = 0.002). The prevalence of advanced fibrosis did not change among subjects who attained SVR, 30% at B/L vs 25% at F/U (p = 0.343). However, advanced fibrosis became more common at F/U among subjects with persistent viremia: 10% at B/L vs 31% at F/U (p = 0.0001). SVR was independently associated with protection from liver fibrosis progression after adjustment for other variables including baseline ALT (p = 0.011), duration of HCV infection and mode of acquisition. CONCLUSION HCV eradication is associated with lower rates of liver fibrosis progression. The data support early treatment to prevent long-term liver complications of HCV infection.", "link"=>"http://www.mendeley.com/research/sustained-virological-response-halts-fibrosis-progression-longterm-followup-study-people-chronic-hep-3", "reader_count"=>3, "reader_count_by_academic_status"=>{"Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}}, "group_count"=>0}

Scopus | Further Information

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