Ciguatoxicity of Gambierdiscus and Fukuyoa species from the Caribbean and Gulf of Mexico
Publication Date
October 18, 2017
Authors
R. Wayne Litaker, William C. Holland, D. Ransom Hardison, Francesco Pisapia, et al
Volume
12
Issue
10
Pages
e0185776
DOI
https://dx.plos.org/10.1371/journal.pone.0185776
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0185776
Scopus
85014836007
Mendeley
http://www.mendeley.com/research/ciguatoxicity-gambierdiscus-fukuyoa-species-caribbean-gulf-mexico
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Mendeley | Further Information

{"title"=>"Ciguatoxicity of Gambierdiscus and Fukuyoa species from the Caribbean and Gulf of Mexico", "type"=>"journal", "authors"=>[{"first_name"=>"R. Wayne", "last_name"=>"Litaker", "scopus_author_id"=>"6603600592"}, {"first_name"=>"William C.", "last_name"=>"Holland", "scopus_author_id"=>"35172881100"}, {"first_name"=>"D. Ransom", "last_name"=>"Hardison", "scopus_author_id"=>"8584881300"}, {"first_name"=>"Francesco", "last_name"=>"Pisapia", "scopus_author_id"=>"56179552200"}, {"first_name"=>"Philipp", "last_name"=>"Hess", "scopus_author_id"=>"57190726296"}, {"first_name"=>"Steven R.", "last_name"=>"Kibler", "scopus_author_id"=>"33667756500"}, {"first_name"=>"Patricia A.", "last_name"=>"Tester", "scopus_author_id"=>"7004159640"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-85014836007", "pui"=>"618802817", "doi"=>"10.1371/journal.pone.0185776", "isbn"=>"1111111111", "sgr"=>"85014836007", "pmid"=>"29045489"}, "id"=>"34a3aafc-de67-3f12-9cdc-47d4a1008a91", "abstract"=>"Dinoflagellate species belonging to the genera Gambierdiscus and Fukuyoa produce ciguatoxins (CTXs), potent neurotoxins that concentrate in fish causing ciguatera fish poisoning (CFP) in humans. While the structures and toxicities of ciguatoxins isolated from fish in the Pacific and Caribbean are known, there are few data on the variation in toxicity between and among species of Gambierdiscus and Fukuyoa. Quantifying the differences in species-specific toxicity is especially important to developing an effective cell-based risk assessment strategy for CFP. This study analyzed the ciguatoxicity of 33 strains representing seven Gambierdiscus and one Fukuyoa species using a cell based Neuro-2a cytotoxicity assay. All strains were isolated from either the Caribbean or Gulf of Mexico. The average toxicity of each species was inversely proportional to growth rate, suggesting an evolutionary trade-off between an investment in growth versus the production of defensive compounds. While there is 2- to 27-fold variation in toxicity within species, there was a 1740-fold difference between the least and most toxic species. Consequently, production of CTX or CTX-like compounds is more dependent on the species present than on the random occurrence of high or low toxicity strains. Seven of the eight species tested (G. belizeanus, G. caribaeus, G. carolinianus, G. carpenteri, Gambierdiscus ribotype 2, G. silvae and F. ruetzleri) exhibited low toxicities, ranging from 0 to 24.5 fg CTX3C equivalents cell-1, relative to G. excentricus, which had a toxicity of 469 fg CTX3C eq. cell-1. Isolates of G. excentricus from other regions have shown similarly high toxicities. If the hypothesis that G. excentricus is the primary source of ciguatoxins in the Atlantic is confirmed, it should be possible to identify areas where CFP risk is greatest by monitoring only G. excentricus abundance using species-specific molecular assays.", "link"=>"http://www.mendeley.com/research/ciguatoxicity-gambierdiscus-fukuyoa-species-caribbean-gulf-mexico", "reader_count"=>10, "reader_count_by_academic_status"=>{"Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1}, "reader_count_by_user_role"=>{"Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Environmental Science"=>1, "Agricultural and Biological Sciences"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}}, "group_count"=>0}

Scopus | Further Information

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