Serum high mobility group box 1 protein levels are not associated with either histological severity or treatment response in children and adults with nonalcoholic fatty liver disease
Publication Date
November 02, 2017
Authors
Katherine P. Yates, Ross Deppe, Megan Comerford, Howard Masuoka, et al
Volume
12
Issue
11
Pages
e0185813
DOI
https://dx.plos.org/10.1371/journal.pone.0185813
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0185813
Scopus
85033372925
Mendeley
http://www.mendeley.com/research/serum-high-mobility-group-box-1-protein-levels-not-associated-either-histological-severity-treatment
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Mendeley | Further Information

{"title"=>"Serum high mobility group box 1 protein levels are not associated with either histological severity or treatment response in children and adults with nonalcoholic fatty liver disease", "type"=>"journal", "authors"=>[{"first_name"=>"Katherine P.", "last_name"=>"Yates", "scopus_author_id"=>"15050033300"}, {"first_name"=>"Ross", "last_name"=>"Deppe", "scopus_author_id"=>"56136111200"}, {"first_name"=>"Megan", "last_name"=>"Comerford", "scopus_author_id"=>"56248167700"}, {"first_name"=>"Howard", "last_name"=>"Masuoka", "scopus_author_id"=>"24073588900"}, {"first_name"=>"Oscar W.", "last_name"=>"Cummings", "scopus_author_id"=>"7006811448"}, {"first_name"=>"James", "last_name"=>"Tonascia", "scopus_author_id"=>"7004645499"}, {"first_name"=>"Naga", "last_name"=>"Chalasani", "scopus_author_id"=>"7005601417"}, {"first_name"=>"Raj", "last_name"=>"Vuppalanchi", "scopus_author_id"=>"6505778591"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85033372925", "sgr"=>"85033372925", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0185813", "isbn"=>"1111111111", "pui"=>"619091652"}, "id"=>"f442a4a8-6831-3a8c-a631-ea4be03e2ba5", "abstract"=>"Aim Serum high mobility group box 1 protein (HMGB1) is a proinflammatory molecule that could potentially serve as a biomarker for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) due to its correlation with degree of liver fibrosis. The aim of the current study was to examine the cross-sectional and longitudinal relationships between serum HMGB1 levels and liver histology in adults and children with NAFLD participating in two large randomized controlled trials. Methods Serum HMGB1 levels were measured at various time points in adults and children with NAFLD, who participated in PIVENS and TONIC clinical trials respectively. PIVENS trial compared vitamin E or pioglitazone to placebo in adults whereas TONIC trial compared vitamin E or metformin to placebo in children. Participants had liver biopsies at baseline and the end of treatment (96 weeks), and liver histology was reviewed by a central committee of study pathologists. Results In the crosssectional analyses (n = 205 for PIVENS and 109 for TONIC), there was no significant relationship between serum HMGB1 levels and histological features such as steatosis, ballooning, inflammation, fibrosis, or presence of steatohepatitis in either adults or children. Serum HMGB1 levels did not change significantly during treatment either with placebo, vitamin E therapy (P = 0.81) or pioglitazone (P = 0.09) in the PIVENS trial. Similarly, serum HMGB1 levels did not change significantly during treatment either with placebo, metformin (P = 0.15) or vitamin E (P = 0.23) in the TONIC trial. In the longitudinal analyses (n = 105 for PIVENS and 109 for TONIC), changes in serum HMGB1 levels did not correlate with histologic improvement or resolution of NASH in either adults or children. There was no relationship between serum HMGB1 and ALT levels in either adults or children with NAFLD. Conclusion Serum HMGB1 levels were not associated with histological severity or treatment response in either children or adults with NAFLD.", "link"=>"http://www.mendeley.com/research/serum-high-mobility-group-box-1-protein-levels-not-associated-either-histological-severity-treatment", "reader_count"=>3, "reader_count_by_academic_status"=>{"Other"=>1, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Other"=>1, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>2}, "reader_count_by_subdiscipline"=>{"Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>0}

Scopus | Further Information

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