The role of IL-6 in pathogenesis of abdominal aortic aneurysm in mice
Publication Date
October 05, 2017
Journal
PLOS ONE
Authors
Michihide Nishihara, Hiroki Aoki, Satoko Ohno, Aya Furusho, et al
Volume
12
Issue
10
Pages
e0185923
DOI
https://dx.plos.org/10.1371/journal.pone.0185923
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0185923
Scopus
85030763088
Mendeley
http://www.mendeley.com/research/role-il6-pathogenesis-abdominal-aortic-aneurysm-mice
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"The role of IL-6 in pathogenesis of abdominal aortic aneurysm in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Michihide", "last_name"=>"Nishihara", "scopus_author_id"=>"56704534500"}, {"first_name"=>"Hiroki", "last_name"=>"Aoki", "scopus_author_id"=>"35975614200"}, {"first_name"=>"Satoko", "last_name"=>"Ohno", "scopus_author_id"=>"53881619400"}, {"first_name"=>"Aya", "last_name"=>"Furusho", "scopus_author_id"=>"53881294300"}, {"first_name"=>"Saki", "last_name"=>"Hirakata", "scopus_author_id"=>"56582521100"}, {"first_name"=>"Norifumi", "last_name"=>"Nishida", "scopus_author_id"=>"56581324800"}, {"first_name"=>"Sohei", "last_name"=>"Ito", "scopus_author_id"=>"57198346997"}, {"first_name"=>"Makiko", "last_name"=>"Hayashi", "scopus_author_id"=>"57195993744"}, {"first_name"=>"Tsutomu", "last_name"=>"Imaizumi", "scopus_author_id"=>"55892699400"}, {"first_name"=>"Yoshihiro", "last_name"=>"Fukumoto", "scopus_author_id"=>"57200259897"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"28982132", "sgr"=>"85030763088", "doi"=>"10.1371/journal.pone.0185923", "scopus"=>"2-s2.0-85030763088", "pui"=>"618616449", "isbn"=>"1111111111", "issn"=>"19326203"}, "id"=>"711dea97-94d7-37cf-975a-efb36fa253b9", "abstract"=>"Although the pathogenesis of abdominal aortic aneurysm (AAA) remains unclear, evidence is accumulating to support a central role for inflammation. Inflammatory responses are coordinated by various soluble cytokines of which IL-6 is one of the major proinflammatory cytokines. In this study we examined the role of IL-6 in the pathogenesis of experimental AAA induced by a periaortic exposure to CaCl2 in mice. We now report that the administration of MR16-1, a neutralizing monoclonal antibody specific for the mouse IL-6 receptor, mildly suppressed the development of AAA. The inhibition of IL-6 signaling provoked by MR16-1 also resulted in a suppression of Stat3 activity. Conversely, no significant changes in either NFκB activity, Jnk activity or the expression of matrix metalloproteinases (Mmp) -2 and -9 were identified. Transcriptome analyses revealed that MR16-1-sensitive genes encode chemokines and their receptors, as well as factors that regulate vascular permeability and cell migration. Imaging cytometric analyses then consistently demonstrated reduced cellular infiltration for MR16-1-treated AAA. These results suggest that IL-6 plays an important but limited role in AAA pathogenesis, and primarily regulates cell migration and infiltration. These data would also suggest that IL-6 activity may play an important role in scenarios of continuous cellular infiltration, possibly including human AAA.", "link"=>"http://www.mendeley.com/research/role-il6-pathogenesis-abdominal-aortic-aneurysm-mice", "reader_count"=>4, "reader_count_by_academic_status"=>{"Researcher"=>1, "Other"=>3}, "reader_count_by_user_role"=>{"Researcher"=>1, "Other"=>3}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85030763088"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85030763088?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85030763088&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85030763088&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85030763088", "dc:identifier"=>"SCOPUS_ID:85030763088", "eid"=>"2-s2.0-85030763088", "dc:title"=>"The role of IL-6 in pathogenesis of abdominal aortic aneurysm in mice", "dc:creator"=>"Nishihara M.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"12", "prism:issueIdentifier"=>"10", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-10-01", "prism:coverDisplayDate"=>"October 2017", "prism:doi"=>"10.1371/journal.pone.0185923", "citedby-count"=>"11", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Kurume University School of Medicine", "affiliation-city"=>"Kurume", "affiliation-country"=>"Japan"}], "pubmed-id"=>"28982132", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0185923", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Counter

  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"112", "xml_views"=>"8", "html_views"=>"224"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"165"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"305"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"4", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"3", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"13"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"10"}

PMC Usage Stats

  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"40", "full-text"=>"42", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"31", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"46", "full-text"=>"40", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"22", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"33", "full-text"=>"27", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"19", "full-text"=>"24", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
Loading … Spinner
There are currently no alerts