Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells
Publication Date
October 06, 2017
Authors
Masashi Ohno, Atsushi Nishida, Yoshihiko Sugitani, Kyohei Nishino, et al
Volume
12
Issue
10
Pages
e0185999
DOI
https://dx.plos.org/10.1371/journal.pone.0185999
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0185999
Scopus
85030696316
Mendeley
http://www.mendeley.com/research/nanoparticle-curcumin-ameliorates-experimental-colitis-via-modulation-gut-microbiota-induction-regul-1
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Mendeley | Further Information

{"title"=>"Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells", "type"=>"journal", "authors"=>[{"first_name"=>"Masashi", "last_name"=>"Ohno", "scopus_author_id"=>"57037899400"}, {"first_name"=>"Atsushi", "last_name"=>"Nishida", "scopus_author_id"=>"7102999671"}, {"first_name"=>"Yoshihiko", "last_name"=>"Sugitani", "scopus_author_id"=>"57093464500"}, {"first_name"=>"Kyohei", "last_name"=>"Nishino", "scopus_author_id"=>"57195349864"}, {"first_name"=>"Osamu", "last_name"=>"Inatomi", "scopus_author_id"=>"8076700000"}, {"first_name"=>"Mitsushige", "last_name"=>"Sugimoto", "scopus_author_id"=>"8265532300"}, {"first_name"=>"Masahiro", "last_name"=>"Kawahara", "scopus_author_id"=>"57195347102"}, {"first_name"=>"Akira", "last_name"=>"Andoh", "scopus_author_id"=>"57078176700"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85030696316", "pmid"=>"28985227", "pui"=>"618656956", "issn"=>"19326203", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85030696316", "doi"=>"10.1371/journal.pone.0185999"}, "id"=>"f7f2e876-28cd-38e3-b142-fc398606444c", "abstract"=>"BACKGROUND AND AIMS Curcumin is a hydrophobic polyphenol derived from turmeric, a traditional Indian spice. Curcumin exhibits various biological functions, but its clinical application is limited due to its poor absorbability after oral administration. A newly developed nanoparticle curcumin shows improved absorbability in vivo. In this study, we examined the effects of nanoparticle curcumin (named Theracurmin) on experimental colitis in mice. METHODS BALB/c mice were fed with 3% dextran sulfate sodium (DSS) in water. Mucosal cytokine expression and lymphocyte subpopulation were analyzed by real-time PCR and flow cytometry, respectively. The profile of the gut microbiota was analyzed by real-time PCR. RESULTS Treatment with nanoparticle curcumin significantly attenuated body weight loss, disease activity index, histological colitis score and significantly improved mucosal permeability. Immunoblot analysis showed that NF-κB activation in colonic epithelial cells was significantly suppressed by treatment with nanoparticle curcumin. Mucosal mRNA expression of inflammatory mediators was significantly suppressed by treatment with nanoparticle curcumin. Treatment with nanoparticle curcumin increased the abundance of butyrate-producing bacteria and fecal butyrate level. This was accompanied by increased expansion of CD4+ Foxp3+ regulatory T cells and CD103+ CD8α- regulatory dendritic cells in the colonic mucosa. CONCLUSIONS Treatment with nanoparticle curcumin suppressed the development of DSS-induced colitis potentially via modulation of gut microbial structure. These responses were associated with induction of mucosal immune cells with regulatory properties. Nanoparticle curcumin is one of the promising candidates as a therapeutic option for the treatment of IBD.", "link"=>"http://www.mendeley.com/research/nanoparticle-curcumin-ameliorates-experimental-colitis-via-modulation-gut-microbiota-induction-regul-1", "reader_count"=>12, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>2, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>2, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>3, "Immunology and Microbiology"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>2}

Scopus | Further Information

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