Advanced maternal age and adverse pregnancy outcomes: A systematic review and meta-analysis
Publication Date
October 17, 2017
Authors
Samantha C. Lean, Hayley Derricott, Rebecca L. Jones & Alexander E. P. Heazell
Volume
12
Issue
10
Pages
e0186287
DOI
https://dx.plos.org/10.1371/journal.pone.0186287
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0186287
Scopus
85031892364
Mendeley
http://www.mendeley.com/research/advanced-maternal-age-adverse-pregnancy-outcomes-systematic-review-metaanalysis-2
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Advanced maternal age and adverse pregnancy outcomes: A systematic review and meta-analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Samantha C.", "last_name"=>"Lean"}, {"first_name"=>"Hayley", "last_name"=>"Derricott"}, {"first_name"=>"Rebecca L.", "last_name"=>"Jones"}, {"first_name"=>"Alexander E. P.", "last_name"=>"Heazell"}], "year"=>2017, "source"=>"PLOS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0186287", "issn"=>"1932-6203", "pmid"=>"29040334", "isbn"=>"1111111111"}, "id"=>"5161df44-a798-3177-85a8-8b064418d730", "abstract"=>"BACKGROUND Advanced maternal age (AMA; ≥35 years) is an increasing trend and is reported to be associated with various pregnancy complications. OBJECTIVE To determine the risk of stillbirth and other adverse pregnancy outcomes in women of AMA. SEARCH STRATEGY Embase, Medline (Ovid), Cochrane Database of Systematic Reviews, ClinicalTrials.gov, LILACS and conference proceedings were searched from ≥2000. SELECTION CRITERIA Cohort and case-control studies reporting data on one or more co-primary outcomes (stillbirth or fetal growth restriction (FGR)) and/or secondary outcomes in mothers ≥35 years and <35 years. DATA COLLECTION AND ANALYSIS The effect of age on pregnancy outcome was investigated by random effects meta-analysis and meta-regression. Stillbirth rates were correlated to rates of maternal diabetes, obesity, hypertension and use of assisted reproductive therapies (ART). MAIN RESULTS Out of 1940 identified titles; 63 cohort studies and 12 case-control studies were included in the meta-analysis. AMA increased the risk of stillbirth (OR 1.75, 95%CI 1.62 to 1.89) with a population attributable risk of 4.7%. Similar trends were seen for risks of FGR, neonatal death, NICU unit admission restriction and GDM. The relationship between AMA and stillbirth was not related to maternal morbidity or ART. CONCLUSIONS Stillbirth risk increases with increasing maternal age. This is not wholly explained by maternal co-morbidities and use of ART. We propose that placental dysfunction may mediate adverse pregnancy outcome in AMA. Further prospective studies are needed to directly test this hypothesis.", "link"=>"http://www.mendeley.com/research/advanced-maternal-age-adverse-pregnancy-outcomes-systematic-review-metaanalysis-2", "reader_count"=>21, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>4, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>4, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>1, "Environmental Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>6}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Environmental Science"=>{"Environmental Science"=>1}}, "group_count"=>1}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85031892364"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85031892364?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85031892364&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85031892364&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85031892364", "dc:identifier"=>"SCOPUS_ID:85031892364", "eid"=>"2-s2.0-85031892364", "dc:title"=>"Advanced maternal age and adverse pregnancy outcomes: A systematic review and meta-analysis", "dc:creator"=>"Lean S.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"12", "prism:issueIdentifier"=>"10", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-10-01", "prism:coverDisplayDate"=>"October 2017", "prism:doi"=>"10.1371/journal.pone.0186287", "citedby-count"=>"43", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Manchester University NHS Foundation Trust", "affiliation-city"=>"Manchester", "affiliation-country"=>"United Kingdom"}, {"@_fa"=>"true", "affilname"=>"University of Manchester", "affiliation-city"=>"Manchester", "affiliation-country"=>"United Kingdom"}], "pubmed-id"=>"29040334", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e0186287", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Twitter

Counter

  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"185", "xml_views"=>"9", "html_views"=>"1148"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"78", "xml_views"=>"6", "html_views"=>"445"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"56", "xml_views"=>"2", "html_views"=>"395"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"92", "xml_views"=>"0", "html_views"=>"282"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"75", "xml_views"=>"1", "html_views"=>"196"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"66", "xml_views"=>"1", "html_views"=>"227"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"81", "xml_views"=>"2", "html_views"=>"189"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"95", "xml_views"=>"1", "html_views"=>"182"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"47", "xml_views"=>"5", "html_views"=>"141"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"38", "xml_views"=>"4", "html_views"=>"121"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"55", "xml_views"=>"1", "html_views"=>"158"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"60", "xml_views"=>"3", "html_views"=>"180"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"77", "xml_views"=>"4", "html_views"=>"198"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"62", "xml_views"=>"2", "html_views"=>"189"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"101"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"56", "xml_views"=>"0", "html_views"=>"115"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"64", "xml_views"=>"3", "html_views"=>"152"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"89", "xml_views"=>"0", "html_views"=>"220"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"69", "xml_views"=>"4", "html_views"=>"215"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"84", "xml_views"=>"0", "html_views"=>"204"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"59", "xml_views"=>"0", "html_views"=>"150"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"52", "xml_views"=>"2", "html_views"=>"189"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"73", "xml_views"=>"0", "html_views"=>"171"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"118", "xml_views"=>"2", "html_views"=>"204"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"93", "xml_views"=>"1", "html_views"=>"190"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"37", "xml_views"=>"1", "html_views"=>"84"}

PMC Usage Stats

  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"250", "full-text"=>"300", "pdf"=>"176", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"79", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"142", "full-text"=>"158", "pdf"=>"74", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"33", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"167", "full-text"=>"179", "pdf"=>"82", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"51", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"245", "full-text"=>"268", "pdf"=>"85", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"31", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"312", "full-text"=>"335", "pdf"=>"82", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"23", "supp-data"=>"4", "cited-by"=>"2", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"313", "full-text"=>"366", "pdf"=>"80", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"9", "cited-by"=>"2", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"384", "full-text"=>"468", "pdf"=>"88", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"34", "supp-data"=>"5", "cited-by"=>"3", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"313", "full-text"=>"331", "pdf"=>"44", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"360", "full-text"=>"417", "pdf"=>"78", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"31", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"300", "full-text"=>"341", "pdf"=>"81", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"24", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"475", "full-text"=>"502", "pdf"=>"56", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"233", "full-text"=>"252", "pdf"=>"44", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"358", "full-text"=>"402", "pdf"=>"58", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"14", "cited-by"=>"2", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"313", "full-text"=>"347", "pdf"=>"64", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"397", "full-text"=>"479", "pdf"=>"98", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"505", "full-text"=>"599", "pdf"=>"96", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"26", "supp-data"=>"12", "cited-by"=>"2", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"566", "full-text"=>"633", "pdf"=>"64", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"6", "cited-by"=>"3", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"578", "full-text"=>"669", "pdf"=>"72", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"28", "supp-data"=>"15", "cited-by"=>"2", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"468", "full-text"=>"534", "pdf"=>"53", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"501", "full-text"=>"580", "pdf"=>"60", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"3", "cited-by"=>"4", "year"=>"2019", "month"=>"9"}
Loading … Spinner
There are currently no alerts