The endocannabinoid system in canine Steroid-Responsive Meningitis-Arteritis and Intraspinal Spirocercosis
Publication Date
February 06, 2018
Authors
Jessica Freundt Revilla, Franciska Heinrich, Alexander Zoerner, Felix Gesell, et al
Volume
13
Issue
2
Pages
e0187197
DOI
https://dx.plos.org/10.1371/journal.pone.0187197
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0187197
Scopus
85041693374
Mendeley
http://www.mendeley.com/research/endocannabinoid-system-canine-steroidresponsive-meningitisarteritis-intraspinal-spirocercosis
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Mendeley | Further Information

{"title"=>"The endocannabinoid system in canine steroid-responsive meningitis-arteritis and intraspinal spirocercosis", "type"=>"journal", "authors"=>[{"first_name"=>"Jessica", "last_name"=>"Freundt-Revilla", "scopus_author_id"=>"57193109825"}, {"first_name"=>"Franciska", "last_name"=>"Heinrich", "scopus_author_id"=>"57200558611"}, {"first_name"=>"Alexander", "last_name"=>"Zoerner", "scopus_author_id"=>"24482600800"}, {"first_name"=>"Felix", "last_name"=>"Gesell", "scopus_author_id"=>"55974528800"}, {"first_name"=>"Martin", "last_name"=>"Beyerbach", "scopus_author_id"=>"6602626657"}, {"first_name"=>"Merav", "last_name"=>"Shamir", "scopus_author_id"=>"7003647924"}, {"first_name"=>"Anna", "last_name"=>"Oevermann", "scopus_author_id"=>"15137103500"}, {"first_name"=>"Wolfgang", "last_name"=>"Baumgärtner", "scopus_author_id"=>"7203023235"}, {"first_name"=>"Andrea", "last_name"=>"Tipold", "scopus_author_id"=>"56232907700"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"620530044", "pmid"=>"29408878", "doi"=>"10.1371/journal.pone.0187197", "issn"=>"19326203", "scopus"=>"2-s2.0-85041693374", "sgr"=>"85041693374", "isbn"=>"1111111111"}, "id"=>"813f1169-b48e-392b-be58-4bb742a3f917", "abstract"=>"Endocannabinoids (ECs) are involved in immunomodulation, neuroprotection and control of inflammation in the central nervous system (CNS). Activation of cannabinoid type 2 receptors (CB2) is known to diminish the release of pro-inflammatory factors and enhance the secretion of anti-inflammatory cytokines. Furthermore, the endocannabinoid 2-arachidonoyl glycerol (2-AG) has been proved to induce the migration of eosinophils in a CB2 receptor-dependent manner in peripheral blood and activate neutrophils independent of CB activation in humans. The aim of the current study was to investigate the influence of the endocannabinoid system in two different CNS inflammatory diseases of the dog, i.e. Steroid-Responsive Meningitis-Arteritis (SRMA) and Intraspinal Spirocercosis (IS). The two main endocannabinoids, anandamide (AEA) and 2-AG, were quantified by mass spectrometry in CSF and serum samples of dogs affected with Steroid- Responsive Meningitis-Arteritis in the acute phase (SRMA A), SRMA under treatment with prednisolone (SRMA Tr), intraspinal Spirocercosis and healthy dogs. Moreover, expression of the CB2 receptor was evaluated in inflammatory lesions of SRMA and IS and compared to healthy controls using immunohistochemistry (IHC). Dogs with SRMA A showed significantly higher concentrations of total AG and AEA in serum in comparison to healthy controls and in CSF compared to SRMA Tr (p<0.05). Furthermore, dogs with IS displayed the highest ECs concentrations in CSF, being significantly higher than in CSF samples of dogs with SRMA A (p<0.05). CSF samples that demonstrated an eosinophilic pleocytosis had the highest levels of ECs, exceeding those with neutrophilic pleocytosis, suggesting that ECs have a major effect on migration of eosinophils in the CSF. Furthermore, CB2 receptor expression was found in glial cells in the spinal cord of healthy dogs, whereas in dogs with SRMA and IS, CB2 was strongly expressed not only in glial cells but also on the cellular surface of infiltrating leukocytes (i.e. neutrophils, eosinophils, lymphocytes, plasma cells, and macrophages) at lesion sites. The present study revealed an upregulated endocannabinoid system in dogs with inflammatory CNS diseases, highlighting the endocannabinoid system as a potential target for treatment of inflammatory CNS diseases.", "link"=>"http://www.mendeley.com/research/endocannabinoid-system-canine-steroidresponsive-meningitisarteritis-intraspinal-spirocercosis", "reader_count"=>10, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>2, "Student > Postgraduate"=>1, "Student > Bachelor"=>5, "Student > Doctoral Student"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>2, "Student > Postgraduate"=>1, "Student > Bachelor"=>5, "Student > Doctoral Student"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>1, "Veterinary Science and Veterinary Medicine"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>3}}, "group_count"=>0}

Scopus | Further Information

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