Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial
Publication Date
December 07, 2017
Authors
Anas Raed, Jigar Bhagatwala, Haidong Zhu, Norman K. Pollock, et al
Volume
12
Issue
12
Pages
e0188424
DOI
https://dx.plos.org/10.1371/journal.pone.0188424
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0188424
Scopus
85037646637
Mendeley
http://www.mendeley.com/research/dose-responses-vitamin-d3-supplementation-arterial-stiffness-overweight-african-americans-vitamin-d
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Mendeley | Further Information

{"title"=>"Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial", "type"=>"journal", "authors"=>[{"first_name"=>"Anas", "last_name"=>"Raed"}, {"first_name"=>"Jigar", "last_name"=>"Bhagatwala"}, {"first_name"=>"Haidong", "last_name"=>"Zhu"}, {"first_name"=>"Norman K.", "last_name"=>"Pollock"}, {"first_name"=>"Samip J.", "last_name"=>"Parikh"}, {"first_name"=>"Ying", "last_name"=>"Huang"}, {"first_name"=>"Robyn", "last_name"=>"Havens"}, {"first_name"=>"Ishita", "last_name"=>"Kotak"}, {"first_name"=>"De-Huang", "last_name"=>"Guo"}, {"first_name"=>"Yanbin", "last_name"=>"Dong"}], "year"=>2017, "source"=>"PLOS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0188424", "isbn"=>"1111111111", "pmid"=>"29216203"}, "id"=>"59d77061-7ed5-36b6-8789-288e6feb0795", "abstract"=>"BACKGROUND Clinical trials are scant and equivocal on whether vitamin D can ameliorate arterial stiffness, particularly in populations at high risk for vitamin D deficiency and cardiovascular disease (CVD). This study determined the dose-response effects of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency. METHODS Seventy overweight African Americans (aged 13-45 years) with serum 25-hydroxyvitamin D [25(OH)D] levels ≤ 20 ng/mL were randomized to monthly oral supplementation of 18,000 IU (~600 IU/day, n = 17), 60,000 IU (~2000 IU/day, n = 18), or 120,000 IU (~4000 IU/day, n = 18) of vitamin D3 or placebo (n = 17) for 16-weeks. The arterial stiffness measurements, carotid-femoral pulse wave velocity (PWV) and carotid-radial PWV, were assessed by applanation tonometry at baseline and 16 weeks. RESULTS Vitamin D3 supplementation demonstrated a dose-response increase in serum 25(OH)D concentrations between groups (P<0.01). A significant downward linear trend was observed for carotid-femoral PWV (P<0.01), as the mean changes in carotid-femoral PWV across the four treatment groups were 0.13 m/s (95% CI: -0.24, 0.51 m/s) for placebo, 0.02 m/s (95% CI: -0.34, 0.38 m/s) for 600 IU/day group, -0.11 m/s (95% CI: -0.50, 0.27 m/s) for the 2,000 IU/day group, and -0.70 m/s (95% CI: -1.07, -0.32 m/s) for the 4,000 IU/day group. Findings were similar for carotid-radial PWV (P = 0.03), as the mean changes in carotid-radial PWV across the four treatment groups were 0.24 m/s (95% CI: -0.45, 0.92 m/s) for placebo, 0.09 m/s (95% CI: -0.54, 0.73 m/s) for 600 IU/day group, -0.57 m/s (95% CI: -1.20, 0.07 m/s) for the 2,000 IU/day group, and -0.61 m/s (95% CI: -1.25, 0.02 m/s) for the 4,000 IU/day group. CONCLUSION Arterial stiffness was improved by vitamin D3 supplementation in a dose-response manner in overweight African Americans with vitamin D deficiency.", "link"=>"http://www.mendeley.com/research/dose-responses-vitamin-d3-supplementation-arterial-stiffness-overweight-african-americans-vitamin-d", "reader_count"=>22, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>6, "Student > Bachelor"=>4, "Lecturer"=>2, "Professor"=>1, "Unspecified"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>6, "Student > Bachelor"=>4, "Lecturer"=>2, "Professor"=>1, "Unspecified"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>1, "Sports and Recreations"=>1, "Social Sciences"=>6, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>6}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>1}

Scopus | Further Information

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