Molecular characterization of hepatitis B virus in Bangladesh reveals a highly recombinant population
Publication Date
December 07, 2017
Authors
Saif Ullah Munshi, Thanh Thi Thanh Tran, Truc Nhu Thanh Vo, Shahina Tabassum, et al
Volume
12
Issue
12
Pages
e0188944
DOI
https://dx.plos.org/10.1371/journal.pone.0188944
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0188944
Scopus
85037607033
Mendeley
http://www.mendeley.com/research/molecular-characterization-hepatitis-b-virus-bangladesh-reveals-highly-recombinant-population
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Mendeley | Further Information

{"title"=>"Molecular characterization of hepatitis B virus in Bangladesh reveals a highly recombinant population", "type"=>"journal", "authors"=>[{"first_name"=>"Saif Ullah", "last_name"=>"Munshi", "scopus_author_id"=>"23485787000"}, {"first_name"=>"Thanh Thi Thanh", "last_name"=>"Tran", "scopus_author_id"=>"57199170424"}, {"first_name"=>"Truc Nhu Thanh", "last_name"=>"Vo", "scopus_author_id"=>"57199145680"}, {"first_name"=>"Shahina", "last_name"=>"Tabassum", "scopus_author_id"=>"7003527798"}, {"first_name"=>"Nahida", "last_name"=>"Sultana", "scopus_author_id"=>"57193803470"}, {"first_name"=>"Trang Hoa", "last_name"=>"Nguyen", "scopus_author_id"=>"57199179244"}, {"first_name"=>"Munira", "last_name"=>"Jahan", "scopus_author_id"=>"41861653900"}, {"first_name"=>"Chau Ngoc", "last_name"=>"Le", "scopus_author_id"=>"57199180720"}, {"first_name"=>"Stephen", "last_name"=>"Baker", "scopus_author_id"=>"7403308306"}, {"first_name"=>"Motiur", "last_name"=>"Rahman", "scopus_author_id"=>"7404134717"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-85037607033", "sgr"=>"85037607033", "pui"=>"619552792", "isbn"=>"1111111111", "pmid"=>"29216251", "doi"=>"10.1371/journal.pone.0188944"}, "id"=>"3ccc90eb-82cf-3764-8d62-0ace1c6dbe8a", "abstract"=>"The natural history and treatment outcome of hepatitis B viruses (HBV) infection is largely dependent on genotype, subgenotype, and the presence or absence of virulence associated mutations. We have studied the prevalence of genotype and subgenotype as well as virulence and drug resistance associated mutations and prevalence of recombinant among HBV from Bangladesh. A prospective cross-sectional study was conducted among treatment naïve chronic HBV patients attending at Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh for HBV viral load assessment between June and August 2015. Systematical selected 50% of HBV DNA positive patients (every second patient) were enrolled. Biochemical and serological markers for HBV infection and whole genome sequencing (WGS) was performed on virus positive sample. Genotype, subgenotype, virulence, nucleos(t)ide analogue (NA) resistance (NAr) mutations, and the prevalence of recombinant isolates were determined. Among 114 HBV DNA positive patients, 57 were enrolled in the study and 53 HBV WGS were generated for downstream analysis. Overall, 38% (22/57) and 62% (35/57) of patients had acute and chronic HBV infections, respectively. The prevalence of genotypes A, C, and D was 18.9% (10/53), 45.3% (24/53), and 35.8% (19/53), respectively. Among genotype A, C and D isolates subgenotype A1 (90%; 9/10), C1 (87.5%; 21/24) and D2 (78.9%; 15/19) predominates. The acute infection, virulence associated mutations, and viral load was higher in the genotype D isolates. Evidence of recombination was identified in 22.6% (12/53) of the HBV isolates including 20.0% (2/10), and 16.7% (4/24) and 31.6% (6/19) of genotype A, C and D isolates, respectively. The prevalence of recombination was higher in chronic HVB patients (32.2%; 10/31 versus 9.1%; 2/22); p<0.05. NAr mutations were identified in 47.2% (25/53) of the isolates including 33.9% novel mutations (18/53). HBV genotype C and D predominated in this population in Bangladesh; a comparatively high prevalence of recombinant HBV are circulating in this setting.", "link"=>"http://www.mendeley.com/research/molecular-characterization-hepatitis-b-virus-bangladesh-reveals-highly-recombinant-population", "reader_count"=>7, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>1}

Scopus | Further Information

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