Yew (Taxus) intoxication in free-ranging cervids
Publication Date
December 27, 2017
Authors
Kjell Handeland, Turid Vikøren, Terje D. Josefsen, Knut Madslien, et al
Volume
12
Issue
12
Pages
e0188961
DOI
https://dx.plos.org/10.1371/journal.pone.0188961
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0188961
Scopus
85039741480
Mendeley
http://www.mendeley.com/research/yew-taxus-intoxication-freeranging-cervids
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Mendeley | Further Information

{"title"=>"Yew (Taxus) intoxication in free-ranging cervids", "type"=>"journal", "authors"=>[{"first_name"=>"Kjell", "last_name"=>"Handeland", "scopus_author_id"=>"7003666979"}, {"first_name"=>"Turid", "last_name"=>"Vikøren", "scopus_author_id"=>"55920230100"}, {"first_name"=>"Terje D.", "last_name"=>"Josefsen", "scopus_author_id"=>"6603463880"}, {"first_name"=>"Knut", "last_name"=>"Madslien", "scopus_author_id"=>"25227549400"}, {"first_name"=>"Belinda", "last_name"=>"Valdecanas", "scopus_author_id"=>"57200116186"}, {"first_name"=>"Silvio", "last_name"=>"Uhlig", "scopus_author_id"=>"7005635680"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85039741480", "doi"=>"10.1371/journal.pone.0188961", "scopus"=>"2-s2.0-85039741480", "pui"=>"619942992", "issn"=>"19326203"}, "id"=>"b68ca3e1-aca8-33b5-8574-8deb506bccf9", "abstract"=>"© 2017 Handeland et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Wild ruminants, including deer species (cervids) have incorrectly been regarded as refractory to yew (Taxus) intoxication. This assumption has been based upon anecdotal observations of individual deer browsing on yew over time without apparent adverse effect. A single case of yew intoxication was reported in a free-ranging Norwegian moose (Alces alces) in 2008. The current report describes five additional cases of yew toxicosis in moose, seven in roe deer (Capreolus capreolus) and two in reindeer (Rangifer tarandus tarandus), all in Norway. The animals were found dead during the winter, close to or within gardens containing yew plants showing signs of browsing. Gross findings included lung congestion and edema, thoracic and pericardial effusion, bilateral heart dilatation, epi- and endocardial hemorrhage, and enlarged (congested) spleen. Yew plant remnants were detected in the rumen of all animals with the exception of a single moose. Histology revealed multifocal acute myocardial degeneration and necrosis with hemorrhage in roe deer, but not in the two other species. A qualitative high performance liquid chromatography–ion trap mass spectrometry analysis was used to tentatively identify five major Taxus alkaloids (taxines) in crude yew extracts and in heart and liver samples from the moose cases. All five major taxines were detected with good signal/noise ratio in tissue samples from the four moose with visible ruminal yew content, whereas lower levels of taxines were detected in the moose without visible ruminal yew content. Possible differences in interspecies tolerance to taxines and role of individual protective adaptation are discussed.", "link"=>"http://www.mendeley.com/research/yew-taxus-intoxication-freeranging-cervids", "reader_count"=>1, "reader_count_by_academic_status"=>{"Researcher"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}}, "group_count"=>0}

Scopus | Further Information

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