Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain
Publication Date
December 08, 2017
Authors
Tatsuya Ishii, Yasuyuki Kimura, Masanori Ichise, Keisuke Takahata, et al
Volume
12
Issue
12
Pages
e0189318
DOI
https://dx.plos.org/10.1371/journal.pone.0189318
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0189318
Scopus
85037659201
Mendeley
http://www.mendeley.com/research/anatomical-relationships-between-serotonin-5ht2a-dopamine-d2-receptors-living-human-brain
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Mendeley | Further Information

{"title"=>"Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain", "type"=>"journal", "authors"=>[{"first_name"=>"Tatsuya", "last_name"=>"Ishii"}, {"first_name"=>"Yasuyuki", "last_name"=>"Kimura"}, {"first_name"=>"Masanori", "last_name"=>"Ichise"}, {"first_name"=>"Keisuke", "last_name"=>"Takahata"}, {"first_name"=>"Soichiro", "last_name"=>"Kitamura"}, {"first_name"=>"Sho", "last_name"=>"Moriguchi"}, {"first_name"=>"Manabu", "last_name"=>"Kubota"}, {"first_name"=>"Ming-Rong", "last_name"=>"Zhang"}, {"first_name"=>"Makiko", "last_name"=>"Yamada"}, {"first_name"=>"Makoto", "last_name"=>"Higuchi"}, {"first_name"=>"Yoshinori", "last_name"=>"Okubo"}, {"first_name"=>"Tetsuya", "last_name"=>"Suhara"}], "year"=>2017, "source"=>"PLOS ONE", "identifiers"=>{"issn"=>"1932-6203", "isbn"=>"1111111111", "pmid"=>"29220382", "scopus"=>"2-s2.0-85037659201", "pui"=>"619582199", "doi"=>"10.1371/journal.pone.0189318", "sgr"=>"85037659201"}, "id"=>"eb7a1f9a-c02c-355d-a3da-dc072cfd3578", "abstract"=>"METHODS Seven healthy volunteers underwent PET scans with [18F]altanserin and [11C]FLB 457 for 5-HT2A and D2 receptors, respectively. As a measure of receptor density, a binding potential (BP) was calculated from PET data for 76 cerebral cortical regions. A correlation matrix was calculated between the binding potentials of [18F]altanserin and [11C]FLB 457 for those regions. The regional relationships were investigated using a bicluster analysis of the correlation matrix with an iterative signature algorithm. RESULTS We identified two clusters of regions. The first cluster identified a distinct profile of correlation coefficients between 5-HT2A and D2 receptors, with the former in regions related to sensorimotor integration (supplementary motor area, superior parietal gyrus, and paracentral lobule) and the latter in most cortical regions. The second cluster identified another distinct profile of correlation coefficients between 5-HT2A receptors in the bilateral hippocampi and D2 receptors in most cortical regions. CONCLUSIONS The observation of two distinct clusters in the correlation matrix suggests regional interactions between 5-HT2A and D2 receptors in sensorimotor integration and hippocampal function. A bicluster analysis of the correlation matrix of these neuroreceptors may be beneficial in understanding molecular networks in the human brain.", "link"=>"http://www.mendeley.com/research/anatomical-relationships-between-serotonin-5ht2a-dopamine-d2-receptors-living-human-brain", "reader_count"=>7, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Ph. D. Student"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Ph. D. Student"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}}, "group_count"=>0}

Scopus | Further Information

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