Impaired IFN-α-mediated signal in dendritic cells differentiates active from latent tuberculosis
Publication Date
January 10, 2018
Journal
PLOS ONE
Authors
Stefania Parlato, Teresa Chiacchio, Debora Salerno, Linda Petrone, et al
Volume
13
Issue
1
Pages
e0189477
DOI
https://dx.plos.org/10.1371/journal.pone.0189477
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0189477
Scopus
85040366190
Mendeley
http://www.mendeley.com/research/impaired-ifn%CE%B1mediated-signal-dendritic-cells-differentiates-active-latent-tuberculosis
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Mendeley | Further Information

{"title"=>"Impaired IFN-α-mediated signal in dendritic cells differentiates active from latent tuberculosis", "type"=>"journal", "authors"=>[{"first_name"=>"Stefania", "last_name"=>"Parlato", "scopus_author_id"=>"6603555671"}, {"first_name"=>"Teresa", "last_name"=>"Chiacchio", "scopus_author_id"=>"35193532700"}, {"first_name"=>"Debora", "last_name"=>"Salerno", "scopus_author_id"=>"57090136400"}, {"first_name"=>"Linda", "last_name"=>"Petrone", "scopus_author_id"=>"21934731800"}, {"first_name"=>"Luciano", "last_name"=>"Castiello", "scopus_author_id"=>"37076666400"}, {"first_name"=>"Giulia", "last_name"=>"Romagnoli", "scopus_author_id"=>"20935871900"}, {"first_name"=>"Irene", "last_name"=>"Canini", "scopus_author_id"=>"6507076388"}, {"first_name"=>"Delia", "last_name"=>"Goletti", "scopus_author_id"=>"7004262091"}, {"first_name"=>"Lucia", "last_name"=>"Gabriele", "scopus_author_id"=>"57200949711"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1111111111", "sgr"=>"85040366190", "scopus"=>"2-s2.0-85040366190", "issn"=>"19326203", "pui"=>"620143998", "doi"=>"10.1371/journal.pone.0189477", "pmid"=>"29320502"}, "id"=>"2491c48c-9d5b-39dc-b6b5-3b7601d6c8ce", "abstract"=>"Individuals exposed to Mycobacterium tuberculosis (Mtb) may be infected and remain for the entire life in this condition defined as latent tuberculosis infection (LTBI) or develop active tuberculosis (TB). Among the multiple factors governing the outcome of the infection, dendritic cells (DCs) play a major role in dictating antibacterial immunity. However, current knowledge on the role of the diverse components of human DCs in shaping specific T-cell response during Mtb infection is limited. In this study, we performed a comparative evaluation of peripheral blood circulating DC subsets as well as of monocyte-derived Interferon-α DCs (IFN-DCs) from patients with active TB, subjects with LTBI and healthy donors (HD). The proportion of circulating myeloid BDCA3+ DCs (mDC2) and plasmacytoid CD123+ DCs (pDCs) declined significantly in active TB patients compared to HD, whereas the same subsets displayed a remarkable activation in LTBI subjects. Simultaneously, the differentiation of IFN-DCs from active TB patients resulted profoundly impaired compared to those from LTBI and HD individuals. Importantly, the altered developmental trait of IFN-DCs from active TB patients was associated with down-modulation of IFN-linked genes, marked changes in molecular signaling conveying antigen (Ag) presentation and full inability to induce Ag-specific T cell response. Thus, these data reveal an important role of IFN-α in determining the induction of Mtb-specific immunity.", "link"=>"http://www.mendeley.com/research/impaired-ifn%CE%B1mediated-signal-dendritic-cells-differentiates-active-latent-tuberculosis", "reader_count"=>9, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>5}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Immunology and Microbiology"=>3, "Nursing and Health Professions"=>2}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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