Biologicals and small molecules in psoriasis: A systematic review of economic evaluations
Publication Date
January 03, 2018
Authors
Christian Kromer, Daniel Celis, Diana Sonntag & Wiebke K. Peitsch
Volume
13
Issue
1
Pages
e0189765
DOI
https://dx.plos.org/10.1371/journal.pone.0189765
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0189765
Scopus
85040011165
Mendeley
http://www.mendeley.com/research/biologicals-small-molecules-psoriasis-systematic-review-economic-evaluations
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Mendeley | Further Information

{"title"=>"Biologicals and small molecules in psoriasis: A systematic review of economic evaluations", "type"=>"journal", "authors"=>[{"first_name"=>"Christian", "last_name"=>"Kromer", "scopus_author_id"=>"56600533700"}, {"first_name"=>"Daniel", "last_name"=>"Celis", "scopus_author_id"=>"57200158872"}, {"first_name"=>"Diana", "last_name"=>"Sonntag", "scopus_author_id"=>"54894601600"}, {"first_name"=>"Wiebke K.", "last_name"=>"Peitsch", "scopus_author_id"=>"7003503799"}], "year"=>2018, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "doi"=>"10.1371/journal.pone.0189765", "sgr"=>"85040011165", "scopus"=>"2-s2.0-85040011165", "isbn"=>"1111111111", "pmid"=>"29298315", "pui"=>"620069515"}, "id"=>"5ecc5864-740d-3000-9564-2f0422d5b1c2", "abstract"=>"Biological therapy for moderate-to-severe psoriasis is highly effective but cost-intensive. This systematic review aimed at analyzing evidence on the cost-effectiveness of biological treatment of moderate-to-severe psoriasis. A literature search was conducted until 30/06/2017 in PubMed, Cochrane Library, LILACS, and EconLit. The quality of identified studies was assessed with the checklist by the Centre for Reviews and Dissemination guidance. Out of 482 records, 53 publications were eligible for inclusion. Half of the studies met between 20 and 25 of the quality checklist items, displaying moderate quality. Due to heterogeneity of studies, a qualitative synthesis was conducted. Cost ranges per outcome were enormous across different studies due to diversity in assumptions and model design. Pairwise comparisons of biologicals revealed conflicting results. Overall, adalimumab appeared to be most cost-effective (100% of all aggregated pairwise comparisons), followed by ustekinumab (66.7%), and infliximab (60%). However, in study conclusions most recent publications favored secukinumab and apremilast (75% and 60% of the studies investigating these medications). Accepted willingness-to-pay thresholds varied between 30,000 and 50,000 USD/Quality-Adjusted Life Year (QALY). Three-quarters of studies were financially supported, and in 90% of those, results were consistent with the funder's interest. Economic evaluation of biologicals is crucial for responsible allocation of health care resources. In addition to summarizing the actual evidence this review highlights gaps and needs for future research.", "link"=>"http://www.mendeley.com/research/biologicals-small-molecules-psoriasis-systematic-review-economic-evaluations", "reader_count"=>7, "reader_count_by_academic_status"=>{"Student > Master"=>3, "Other"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Master"=>3, "Other"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "group_count"=>1}

Scopus | Further Information

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